Expertise & Groups

The 13 UPAT Faculty members that participate in SEE-DRUG are affiliated with the Departments of Pharmacy, Medicine, Chemistry and Biology. They combine a publication record comprised of 650 publications, 25 published patents and >14000 citations.

Department of Pharmacy

• Dr. Georgios A. Spyroulias, Assoc Prof. Expertise: NMR Spectroscopy, Protein production & characterisation, Structural Biology, Biomolecular Simulations.
• Dr. Konstantinos Poulas, Assist. Prof. Expertise: Protein production & characterisation, X-ray Crystallography, Molecular modelling and Bioinformatics.
• Dr. George P. Patrinos, Assist. Prof. Expertise: Human genomics, pharmacogenomics, Bioinformatics and genetic databases.

Recent publications

1. Borg J, Georgitsi M, Patrinos GP, Philipsen S et al. Nature Genet 42, 801-5 (2010)
2. Dalkas GA, Chassapis C, Spyroulias GA et al. Biochemistry 49, 10767-9 (2010)
3. Georgitsi M, Poulas K, Tzimas G, Patrinos GP et al. Nucleic Acids Res 39(Database issue), D926-32 (2011)
4. Abriata LA, Banci L, Bertini I, Gkazonis P, Spyroulias GA, et al. Nature Chem Biol 4, 599, (2008)
5. Chen Z, Luo HY, Patrinos GP, et al. Mol Cell Biol 28, 4386-93, (2008)
6. Banci L, Kandias NG, Robinson NJ, Spyroulias GA, et al. Proc Natl Acad Sci USA 103, 8320, (2006)

• Prof. Andreas Papapetropoulos, , Prof. Expertise: Cellular Signalling, Protein-Protein Interactions, Cardiovascular Pharmacology, Inflammation, Pre-clinical drug screening & Development
• Dr. StavrosTopouzis, Assist. Prof. Expertise: use of preclinical, cell-based (in vitro) and animal-based (in vivo) models, for the study of human fibroproliferative and inflammatory diseases.

Recent publications

1. Papapetropoulos A, Pyriochou A, Altaany Z, Yang G, Marazioti A et al. Proc Natl Acad Sci USA 106:21972-7 (2009)
2. Zhou, A. Pyriochou, A. Kotanidou, G. Dalkas, M.V. Eickels, G. Spyroulias, C. Roussos C and Papapetropoulos A. Am J Physiol Heart Circ Physiol. 295:H1763-71 (2008)
3.  G. Haramis, Z. Zhou, A. Pyriochou, M. Koutsilieris, C. Roussos and A. Papapetropoulos. Br J Pharmacol. 155:804-13 (2008)
4.  Z. Zhou, S. Gross, C. Roussos, S Meurer, W. Müller-Esterl and A. Papapetropoulos. J. Biol. Chem. 279:24935-24943, (2004)
5. Dillon SR, Topouzis S et al. Nature Immunol, 5, 752-760 (2004)
6. Papapetropoulos A, Zhou Z, Gerassimou C, Yetik G, Venema RC, Roussos C, et al. Mol Pharmacol. 68:1133-41 (2005)

Department of Medicine

• Nicholas Moschonas, Prof. in Biology & Medical Molecular Genetics, expertise: protein production in bacteria and animal cells, gene expression and functional analysis of proteins, in vitro and cell-based assessment of protein-protein interactions
• Zoi Lygerou, Assistant Professor in Biology, expertise: functional imaging, protein analysis in human cells and yeast, systems biology

Recent publications

1. De Marco V, Lygerou Z, Taraviras S, Perrakis A. et al. Proc Natl Acad Sci USA, 106:19807-12 (2009)
2. Lygeros J, Nurse P, Lygerou Z. et al. Proc Natl Acad Sci USA, 105:12295-12300 (2008)
3. G. Xouri, Taraviras S, Bastiaens PIH, Lygerou Z. et al. EMBO J, 26:1303-1314 (2007)
4. P. Deloukas, M. Kokkinaki, T. Sarafidou, N. K. Moschonas et al. Nature, 429, 375-381 (2004)
5. H. Nishitani, Z. Lygerou, T. Nishimoto, P. Nurse. Nature 404:625-8 (2000)
6. Z. Lygerou, P. Nurse P Science 290:2271-3 (2000)

• Stavros Taraviras, Assistant Professor in Molecular and Cellular Pharmacology, Expertise: generation and analysis of genetically modified mice, isolation and culturing of embryonic haematopoietic and neural stem/progenitor cells, protein expression in different systems, biochemical characterisation of protein complexes, determination of gene and protein expression, live-cell imaging techniques.

Recent publications

1. Karamitros D, Kioussis D, Taraviras S et al. J Immunol 184:2432-41 (2010)
2. De Marco V, Lygerou Z, Taraviras S, Perrakis A. et al. Proc Natl Acad Sci USA 106:19807-12 (2009)
3. Lygerou Z, Taraviras S, Papavassiliou AG, et al. Cancer Res. 67:10899-909 (2007)
4. Roukos V, Taraviras S, Lygerou Z et al. J. Biol. Chem, 282:9346-9357 (2007)
5. G. Xouri, Taraviras S, Bastiaens PIH, Lygerou Z. et al. EMBO J, 26:1303-1314 (2007)
6. Bravou V, Taraviras S, et al. J Pathol. 208:91-9 (2006)

Department of Chemistry

• John Matsoukas, Professor in Organic Chemistry. Expertise: Organic, Peptide synthesis and Characterization of Bioactive Molecules, Structure-Activity Relationship Studies.
• Theodore Tselios, Assistant Professor in Organic Chemistry. Expertise: Rational Design, Synthesis & Characterization of Bioactive Molecules, Biomolecular and Docking Simulations.
• Alexios Vlamis-Gardikas, Assistant Professor in Biochemistry, is a recently appointed faculty member. Expertise: Overexpression and purification of recombinant proteins, protein-protein interaction analysis, bacterial genetics, molecular biology, enzyme assays (especially those related to antioxidant enzymes).

Recent publications

1. Katsara M, Tselios T, Matsoukas J, Apostolopoulos V et al. J Med Chem. 52:214-8 (2009).
2. Deraos G, Tselios T, Apostolopoulos V, Matsoukas J. et al. J Med Chem. 51:7834-4 (2008).
3. Spyranti Z, Matsoukas JM, Tselios TV et al. J Med Chem. 50:6039-47 (2007).
4. Keramida MK, Tselios T, Matsoukas J. et al. J Med Chem. 49:105-10 (2006).
5. Fernandes AP, Vlamis-Gardikas A. et al J Biol Chem. 280:24544-52 (2005).
6. Fladvad M, Vlamis-Gardikas A, Sunnerhagen M et al. J Biol Chem. 280:24553-61 (2005).

Department of Biology

• Kostas Flytzanis, Assoc. Prof. in Cell Biology expertise: gene regulation in early embryonic development of the sea urchin Paracentrotus lividus, study of the transcription factors and SAR studies on nuclear receptors (e.g. COUP-TF; Chicken Ovalbumin Upstream Promoter–Transcription Factors)
• Irene Margiolaki, Lecturer in Structural Biology, Is a recently elected faculty member; expertise: in method development and application of Crystallography & Structural Biology. Extensive knowledge of powder and single crystal diffraction, structure determination, model building, refinement, and skills in Small Angle X-ray Scattering, optical/electron microscopy etc.

Recent publications

1. Ahnfeldt T, Margiolaki I et al. Angew Chem Int Ed 48:5163-5166 (2009).
2. Miller SR, Margiolaki I et al. J Am Chem Soc 130:15967-81 (2008).
3. Margiolaki I, Wright JP, Wilmanns M, Fitch AN, Pinotsis N. J Am Chem Soc 129:11865-71 (2007).
4. Sea Urchin Genome Sequencing Consortium (Flytzanis CN et al.) Science 314:941-952 (2006).
5. Férey G, Mellot-Draznieks C, Serre C, Millange F, Dutour J, Surblé S, Margiolaki I Science 309:2040-2 (2005).
6. Konstantopoulos AK, Flytzanis CN Mol Repro & Dev. 60:147-157 (2001).