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“SEE-DRUG ” is a FP7 - RESEARH POTENTIAL project that aims to the upgrade the Structural Biology capacities of UPAT and to the Establishment of a Center of Excellence for Structure-Based Drug Target chracterization efforts in South-Eastern EU region.
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“SEE-STRUCT” is structure-oriented module of SEE-DRUG project and aims to the structural elucidation of proteins, enzymes and other interesting drug-targets. The tools offered for these efforts are a state-of-the-art high field NMR instrument of 700 MHz equipped with a highly sensitive probe and crystallization robot.
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“SEE-PROT” & “SEE-PHARM” are the protein production and the preclinical evaluation of molecules, modules of SEE-DRUG project. The tools offered for these efforts are protein production and characterization facilities an upgraded confocal microscope, an intravital microscope and myographs.
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High sensetivity probe
Studies in solution
3D Structure determination, mobility, protein-protein interaction, protein-drug interactions
In-cell imaging
Leica Microscope
Tandem Scanner
Additional laser
Sub-cellular ablation in live cells, protein-complexes, protein drug interactions in vivo
Crystal growth
Crystalization trials
Fast & efficient
Crystal growth optimization, screen of protein targes in paraller with NRM Spectroscopy
intravital Microscope
In vivo
Ex vivo
Drug screening for anti-inflammatory compounds, evaluation of vasoactive compounds

Stuctural Biology
NMR & Xray
2H/13C/15N labeling
Selective labeling
Conformation dynamics, Modeling Structure determination, 3D solutions & crystal models, Bioinformatics
Molecular Biology
Biochemical pathways
Protein production
High-yield protein expression, labeling & isolation for structural studies, protein biochemistry
In-cell studies
Functional imaging
Light Microscopy
FRET measurements
Studies of biomolecular functions through Advanced Light Microscopy, Sub-cellular ablations
Vascular Biology
Cell-based assays
Signaling pathways
Monitoring cell processes (migration. proliferation, apoptosis), in vivo & ex vivo assays

Expertise Exchange
Knowledge transfer
Best practices
New applications
Exchange of researchers between UPAT and partnering organizations - EU Centers of excellence
Structural Biology
Workshops and scientific meetings will be organized at UPAT, Advanced training course in NMR
Biomolecular NMR
Life Sciences
Invited talks, Meeting participation & Poster presentations by SEE-DRUG members
Brokerage Events
Meet the expers
Links with industry
Regional Authorities
Colloquia with invited speakers from academia or industry and private sector stakeholders

Other Projects

Prof. A. Papapetropoulos:


“Non-radioactive nitric oxide synthase activity measurement: Development of a biosensor”. Greece-Turkey joint research and technology programs, Greek Secretariat of Research and Technology, 2010-2012 Principle Investigator

“Η2S: a new endogenous signaling molecule with protective actions in the cardiovascular system”, Greek Society for Cardiology, 2011-12, Principle Investigator

“Development of novel Angiogenesis-Modulating Pharmaceuticals by screening of natural compounds and synthetic analogues” Greek Secretariat of Research and Technology, 2010-2013, (Principle Investigator: Leandros Skaltsounis) Co-Investigator

“Hydrogen sulfide a new endogenous regulator of angiogenesis: signaling, physiology/pathophysiology and development of pharmacological inhibitors”. Greek Ministry of Education, 2012-2015, Principle Investigator

European Union

“Gasotransmitters: from basic science to therapeutic applications” European Science Foundation, COST 2011-2015, Chair

Prof. G.A. Spyroulias:


“Greek-Turkish (GSRT-TUBITAK) Joint R+T Collaboration Program” (GSRT, Ministry of Development, GREECE), “Structure-Function Relationship of a new RING finger E3 ubiquitin ligase, a dominant regulator of TGF-b signaling pathway and TGF-b-dependent tumor suppression” 2010-2012, Principal Investigator.

«ΗΡΑΚΛΕΙΤΟΣ ΙΙ: Reinforcing the Human Research Potential through Graduate Research » (Greek Ministry of Education, GREECE), “Expression, Characterization and Structural Investigation through Nuclear Magnetic Resonance (NMR) of the Bacillus anthracis Anthrax Lethal Factor Zn-protease Catalytic Site”, 2011-2014. Principal Investigator.

European Union

FP7-HEALTH-2007 “Neurotrasmitter Cys-loop receptors: structure, function and disease (NeuroCypress)”,, 2008-2012. Partner #15.

FP7-INFRA-2008 “Enhancing Access and Services To East European users towards an efficient and coordinated pan-European pool of NMR capacities to enable global collaborative research and boost technological advancements”,,, 2009-2013. Partner #12.

Upcoming Events

Hot off the Press

porn /div> The NMR Structure of ARKADIA RING Domain (Proteins 2012, 50, 1484-89)

H2S and NO in angiogenesis & vasodilatation (PNAS 2012 in the press)

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International Meetings & Conferences

Journal Club

  • 01 Jan 2012 Starting data of SEE-DRUG project

  • 23 Feb 2012 Kick-off meeting

  • 23 Apr2012 External Advisory Board meeting

  • 29 Apr 2013 700MHz NMR installed