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“SEE-DRUG ” is a FP7 - RESEARH POTENTIAL project that aims to the upgrade the Structural Biology capacities of UPAT and to the Establishment of a Center of Excellence for Structure-Based Drug Target chracterization efforts in South-Eastern EU region.
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“SEE-STRUCT” is structure-oriented module of SEE-DRUG project and aims to the structural elucidation of proteins, enzymes and other interesting drug-targets. The tools offered for these efforts are a state-of-the-art high field NMR instrument of 700 MHz equipped with a highly sensitive probe and crystallization robot.
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“SEE-PROT” & “SEE-PHARM” are the protein production and the preclinical evaluation of molecules, modules of SEE-DRUG project. The tools offered for these efforts are protein production and characterization facilities an upgraded confocal microscope, an intravital microscope and myographs.
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High sensetivity probe
Studies in solution
3D Structure determination, mobility, protein-protein interaction, protein-drug interactions
In-cell imaging
Leica Microscope
Tandem Scanner
Additional laser
Sub-cellular ablation in live cells, protein-complexes, protein drug interactions in vivo
Crystal growth
Crystalization trials
Fast & efficient
Crystal growth optimization, screen of protein targes in paraller with NRM Spectroscopy
intravital Microscope
In vivo
Ex vivo
Drug screening for anti-inflammatory compounds, evaluation of vasoactive compounds

Stuctural Biology
NMR & Xray
2H/13C/15N labeling
Selective labeling
Conformation dynamics, Modeling Structure determination, 3D solutions & crystal models, Bioinformatics
Molecular Biology
Biochemical pathways
Protein production
High-yield protein expression, labeling & isolation for structural studies, protein biochemistry
In-cell studies
Functional imaging
Light Microscopy
FRET measurements
Studies of biomolecular functions through Advanced Light Microscopy, Sub-cellular ablations
Vascular Biology
Cell-based assays
Signaling pathways
Monitoring cell processes (migration. proliferation, apoptosis), in vivo & ex vivo assays

Expertise Exchange
Knowledge transfer
Best practices
New applications
Exchange of researchers between UPAT and partnering organizations - EU Centers of excellence
Structural Biology
Workshops and scientific meetings will be organized at UPAT, Advanced training course in NMR
Biomolecular NMR
Life Sciences
Invited talks, Meeting participation & Poster presentations by SEE-DRUG members
Brokerage Events
Meet the expers
Links with industry
Regional Authorities
Colloquia with invited speakers from academia or industry and private sector stakeholders


Workshop 1: Peptide Synthesis and Protein production/labeling (Tentative date: 4/2012)

The workshop aims to provide an overview of current state-of-art methods and developments in the area of sample preparation and isotope labeling of proteins for structural biology. A special focus will be given to alternative expression host, i.e. beyond E. coli (Dichtyostellim discoideum & C. elegans) and to new strategies for (isotope) uniform or selective/specific labeling and to advanced methodologies applied currently in the synthesis of peptide and peptide-like biopolymers in solid and solution-phase (disulfide-rich peptides, like toxins etc., use of microwave-assisted heating technology and others)
Program of the meeting Book of abstracts

Workshop 2: NMR Basics and Applications in Life Sciences (Tentative date: 04/2013)

A comprehensive workshop, focusing on modern high field NMR spectroscopy in solution, with applications to protein structure, dynamics and functional studies will be organised. State-of-the-art NMR methodologies to solve biological relevant problems and to drug design will be discussed, starting from basic NMR theory and experimental aspects (NMR data acquisition and processing, heteronuclear multidimensional NMR spectroscopy, paramagnetic NMR, automated projection spectroscopy, unsupervised NMR resonance assignment of multi dimensional data, etc.). Basic principal in solid state NMR will be also presented.
Complementay skill course (1 d) for 30 researchers, on 2D/3D homo-/hetero- nuclear NMR data analysis & structure calculations is also foreseen.
Program of the meeting Book of abstracts

Workshop 3: Emerging Analytical Techniques in Protein Characterization (Tentative date: 9/2013)

A workshop, focusing on the state-of-the-art Proteomics methodologies has been planned, to cover the basics on proteins and biophysical methods, protocols in protein purification and protein-protein interactions, electrophoresis and chromatography, electrofocusing, FPLC and HPLC, protein sequencing, spectroscopy and calorimetry, along with Biomolecular Simulation protocols and X-ray Crystallography
Program of the meeting Book of abstracts

Workshop 4: Live cell imaging, Drug Screening & Preclinical assessment (Tentative date: 4/2014)

A workshop, focusing on state-of-the-art methodologies to drug target identification, validation, live cell imaging techniques and their application in determining protein/protein and protein/lead compound interactions and pharmacokinetics. The workshop will cover the following topics: methods in studying drug target - drug interactions, drug discovery/screening, high-throughput live-cell assays for drug screening, QSAR, fluorescence, confocal, multi-photon, spinning-disc and scanned light sheet microscopy and their applications in live-cell and deep tissue imaging, functional live cell imaging techniques for the determination of in-cell protein-protein interactions and modifications and quantitative characterization of protein function, fluorescence Recovery after photobleaching (FRAP), in-cell FRET (fluorescence resonance energy transfer) measurements, fluorescence Lifetime Imaging Microscopy (FLIM), fluorescence Cross-Correlation Spectroscopy (FCCS), etc.
Program of the meeting Book of abstracts

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  • 01 Jan 2012 Starting data of SEE-DRUG project

  • 23 Feb 2012 Kick-off meeting

  • 23 Apr2012 External Advisory Board meeting

  • 29 Apr 2013 700MHz NMR installed