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“SEE-DRUG ” is a FP7 - RESEARH POTENTIAL project that aims to the upgrade the Structural Biology capacities of UPAT and to the Establishment of a Center of Excellence for Structure-Based Drug Target chracterization efforts in South-Eastern EU region.
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“SEE-STRUCT” is structure-oriented module of SEE-DRUG project and aims to the structural elucidation of proteins, enzymes and other interesting drug-targets. The tools offered for these efforts are a state-of-the-art high field NMR instrument of 700 MHz equipped with a highly sensitive probe and crystallization robot.
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“SEE-PROT” & “SEE-PHARM” are the protein production and the preclinical evaluation of molecules, modules of SEE-DRUG project. The tools offered for these efforts are protein production and characterization facilities an upgraded confocal microscope, an intravital microscope and myographs.
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NMR
700MHz
High sensetivity probe
Studies in solution
Conformation/Dynamics
3D Structure determination, mobility, protein-protein interaction, protein-drug interactions
Confocal
In-cell imaging
Leica Microscope
Tandem Scanner
Additional laser
Sub-cellular ablation in live cells, protein-complexes, protein drug interactions in vivo
Robot
Crystal growth
Automation
Crystalization trials
Fast & efficient
Crystal growth optimization, screen of protein targes in paraller with NRM Spectroscopy
Microscopes
Myographs
intravital Microscope
In vivo
Ex vivo
Drug screening for anti-inflammatory compounds, evaluation of vasoactive compounds

Stuctural Biology
NMR & Xray
2H/13C/15N labeling
Selective labeling
Crystallization
Conformation dynamics, Modeling Structure determination, 3D solutions & crystal models, Bioinformatics
Molecular Biology
Biochemistry
Drug-targets
Biochemical pathways
Protein production
High-yield protein expression, labeling & isolation for structural studies, protein biochemistry
Imaging
In-cell studies
Functional imaging
Light Microscopy
FRET measurements
Studies of biomolecular functions through Advanced Light Microscopy, Sub-cellular ablations
Pharmacology
Inflammation
Vascular Biology
Cell-based assays
Signaling pathways
Monitoring cell processes (migration. proliferation, apoptosis), in vivo & ex vivo assays

Expertise Exchange
Twinnings
Knowledge transfer
Best practices
New applications
Exchange of researchers between UPAT and partnering organizations - EU Centers of excellence
Events
Workshops
Structural Biology
Biochemistry
Imaging
Workshops and scientific meetings will be organized at UPAT, Advanced training course in NMR
Dissemination
Conferences
Biomolecular NMR
Life Sciences
Analysis
Invited talks, Meeting participation & Poster presentations by SEE-DRUG members
Brokerage Events
Info-days
Meet the expers
Links with industry
Regional Authorities
Colloquia with invited speakers from academia or industry and private sector stakeholders

Posters

Oral and Poster presentation in international conference, by SEE-DRUG groups:

Oral Presentations

a/a

TITLE

CONFERENCE/PLACE

RESEARCHERS

DATE






2012

2012

2012

2012

1

Conformational plasticity of polypeptides through Biomolecular NMR Spectroscopy

Dept Chemistry, Uof Athens, GR

G.A. Spyroulias

01/2012

2

NMR study of Arkadia E3 ubiquitin ligase domain to correlate Zn(II) coordination with protein architecture, dynamics and function

12th Eurasia

Corfu, GR

«

04/2012

3

Conformational Dynamics and Drug Design Approaches through NMR - Basics and Applications

2nd Summer School of Proteins

Athens, GR

«

05/2012

4

Identifying functionally important residues of Arkadia E3 ubiquitin ligase ring domain in E2 recruitment and E3-E2 interaction

15th HSMC

Athens, GR

«

05/2012

5

NMR Conformational Dynamics and SAR studies of biologically relevant macromolecules

3rd ARCADE Workshop, NHRF,

Athens, GR

«

05/2012

6

The SEE DRUG Project at University of Patras

WIRE2012

Krakow, PL

«

06/2012

7

Insights on the conformational exchange properties of GLIC ECD by solution NMR - Implications on 5/6mer subunit socialization.

4th Neurocypres Annual meeting

Vienna, AT

«

06/2012

8

Elucidating the intrinsic plasticity of the extracellular domain of a prokaryotic nAChR homologue by solution NMR - implications on 5/6mer subunit socialization

Dept Chemistry, Uof Florence

IT

«

06/2012

9

Selective amino acid isotope labeling strategies for solution NMR studies of high-molecular-weight protein drug-targets

32nd EPS,

Athens, GR

«

09/2012

10

NMR-driven Structure Function Correlation studies of Arkadia E3 Ubiquitin Ligase RING domain

6th HECRA

Athens, GR

«

09/2012

11

Conformational Dynamics & Function of Proteins by Solution NMR

Dept Chemistry, Uof Crete, Heraklion, GR

«

11/2012

12

NMR Insights on the functional modulation of the RING domain of Arkadia tumor suppressor.

63rd EEBMB

Herakleion Crete, GR


11/2012

13

NMR Structural Biology at University of Patras & the SEEDRUG Project

3rd EAST-NMR AUM,

Lasko, Slovenia

«

11/2012

14

Solution NMR Studies of E3 Ub Ligase RING and Alphaviruses MACRO Domains

Turkish NMR Meeting

Istanbul, TR

«

12/2012

15

Method Development for Structural Studies: From Materials Science to Structural Biology

IAEA Headquarters, Vienna, AT

«

06/2012

16

Proteins & Powders: Samples, Data & Polymorphism

Macro-molecular Structure of Biological & Non-Biological Materials

Hurghada, Egypt

I. Margiolaki, F. Karavasili & coworkers

11/2012

17

The role of Geminin in the self-renewal and differentiation of hematopoietic stem cells

63rd EEBMB

Herakleion Crete, GR

A. Patmanidi & S. Taraviras

11/2012

18

Pharmacogenomics in developing countries in Europe

World Companion Diagnostics Summit

Frankfurt, DE

G. Patrinos

03/2012

19

Pharmacogenomics and Public health

2nd Latin American Pharmacogenomics Conference,

Rio de Janeiro, BRAZIL

«

06/2012

20

Genomics and rare diseases

8TH Golden Helix Pharmacogenomics Day,

Brno, CZECH REPUBLIC

«

11/2012

2013

2013

2013

2013

21

Soluble guanylyl cyclase: a new look at an old drug target

VIIIth Joint Meeting on Medicinal Chemistry, Lublin, POLAND

A. Papapetropoulos

07/2013

22

GC activators: from molecular pharmacology to clinical use

11TH Symposium of Hellenic Society of Pharmacology, Athens GR

«

03/2013

23

Modulation of H2S levels in cells and tissues using pharmacological agents: advances and pitfalls

2nd European Conference on the Biology of Hydrogen Sulfide, University of Exeter, UK

«

09/2013

24

NO-H2S interactions involve cGMP

6th International Conference on cGMP, cGMP, Ertfurt, DE

«

06/2013

25

Multi-step loading of human Mini Chromosome Maintenance proteins in live human cells

Celebrating the 50th anniversary of the Replicon Theory, Paris, FR

Z. Lygerou

03/2013

26

Controlling self-renewal and fate commitment decisions in stem cell

The European Cancer Stem Cell Research Institute, Cardiff University, UK

S. Taraviras

03/2013

27

The University of Patras Unit of Functional Microscopy and its contribution at basic and applied research

1st Forum of Health, Patras, GR

S. Taraviras

04/2013

28

Geminin, a novel player in cell fate decisions

Weatherall Institute of Molecular Medicine Oxford, UK

S. Taraviras

06/2013

29

Conformational Dynamics of Proteins, Biomolecular Interactions and Drug Design Efforts using NMR

Department of Medicine, University of Patras, GR

G.A.Spyroulias

03/2013

30

State-of-the-art NMR instrumentation & modern NMR applications in the service of Life Sciences

1st Forum of Health, Patras, GR

«

04/2013

31

High-resolution analysis of protein structure, dynamics and interaction through Biomolecular NMR

«NANOTHEO» Workshop University of Patras, GR

«

05/2013

32

NMR conformational dynamics of proteins & protein complexes

2nd Research Coordination Meeting of International Atomic Energy Agency, Rion GR

«

09/2013

33

Conformational Dynamics and Drug Design Approaches through NMR

5th BBBB International Conference 2013, 26-28 September, Athens, GR

«

09/2013

34

Pharmacogenomics and developing countries in Europe

2013 European Annual Human Genetics Conference, Paris, France

G. Patrinos

06/2013

35

Pharmacogenomic applications of whole genome sequencing

5th EMBO meeting, Amsterdam, the Netherlands,

«

09/2013

36

Proteins & Powders: Samples, Data & Structures

Workshop on Powder & Electron Crystallography Patras, GR

I. Margiolaki

07/2013

37

Development of novel methodologies for the study of nano-crystalline materials

2nd Research Coordination Meeting of International Atomic Energy Agency, Rion GR

I. Margiolaki

09/2013

38


Conformational Dynamics and Drug Design Approaches through NMR

5th BBBB International Conference 2013,

Athens GR

G.A.Spyroulias

09/2013

39


SEEDRUG Biomolecular 700MHz NMR Facility

Inauguration of the SEEDRUG Biomolecular NMR Facility, Patras, GR

«

10/2013

40


Geminin, a novel player in cell fate decisions

Beth Israel Deaconess Medical Center, Medical School, Harvard University, USA

S. Taraviras

11/2013

41


Geminin, a novel player in cell fate decisions

Tufts Medical Center, Tufts University School of Medicine, USA

S. Taraviras

11/2013

42


Geminin binds onto distal and proximal elements of HoxA9 and regulates fate commitment decisions of embryonic haemopoietic stem cells

64th EEBMB

Athens, GR

A. Patmanidi,

S. Taraviras

12/2013

43


Effect of non-contact current transfer in protein crystallization: experiments with two model proteins

64th EEBMB

Athens, GR

K.Poulas, G.Lagoumintzis & coworkers

12/2013

2014

2014

2014

2014

44


Macromolecular Powder Diffraction: Past, Present, Future

IYCR2014,

Opening Ceremony, UNESCO, Paris FR

I. Margiolaki

01/2014

45


Geminin, a novel player in cell fate decisions in haematopoietic system

Fleming Institute, Vari, Athens, GR

S. Taraviras

02/2014

46


Structural Biology by NMR:  Knowledge transfer form EU RIs to Greece

ICRI-2014 – Joint Workshop

G.A.Spyroulias

04/2014

47

Macromolecular micro-crystallography: Perspectives in Drug Discovery

15th conference of Medicinal Chemistry, Patras, GR

I. Margiolaki

04/2014

48


Macromolecular Micro-crystallography: Application to Pharmaceutical Proteins

EPDIC14 - The European Powder Diffraction Conference, Aarhus, DK

F. Karavasili & I. Margiolaki

06/2014

49


Macromolecular Micro-crystallography: Application to Pharmaceutical Proteins

EPDIC14 - The European Powder Diffraction Conference, Aarhus, DK

F. Karavasili & I. Margiolaki

06/2014

50

Insights on the conformational plasticity of drug-target proteins

32nd CNC – Trends in Drug Research, 2014

G.A.Spyroulias

05/2014

51

Atomic-level investigation of Structure, Dynamics & Interactions of proteins, through Biomolecular NMR

University of Thessaly

G.A.Spyroulias

05/2014

52

Macromolecular Powder Diffraction: Current status & Future prospects

7th HeCrA

I. Margiolaki

09/2014

53

NMR Conformational Dynamics of La and RRM1 Motifs of La Protein

G.A.Spyroulias

09/2014

54

STAT4 rs7574865 SNP in genetic susceptibility of early-onset Myasthenia Gravis

Pharmacogenomics and Genomic Medicine: Bridging Research and the Clinic

Z. Zagoriti

G.Patrinos, M.Kambouris,

G.Lagoumintzis

09/2014

55

Application of NMR Spectroscopy to the study of biomolecules and pharmaceutical targets

2nd Conference in Pharmaceutical Sciences

UPAT

G.A.Spyroulias

10/2014

56

Atomic-level investigation of Structure, Dynamics & Interactions of proteins, through Biomolecular NMR

Greek NMR Users Mereting

G.A.Spyroulias

10/2014

Poster Presentations

a/a

TITLE

CONFERENCE

RESEARCHERS

DATE






1

NMR study of Arkadia E3 ubiquitin ligase domain to correlate Zn(II) coordination with protein architecture, dynamics and function

12th Eurasia

Corfu, Greece

G.A. Spyroulias

& coworkers

04/2012

2

Identifying functionally important residues of Arkadia E3 ubiquitin ligase ring domain in E2 recruitment and E3-E2 interaction

15th HSMC

Athens

Greece

«

05/2012

3

NMR-driven Structure-Activity correlation study of Arkadia E3 ubiquitin ligase ring domain

12th Chianti Workshop

Florence, Italy

«

06/2012

4

NMR-driven structure-function correlation studies of Arkadia E3 ubiquitin ligase ring finger domain

6th HECRA

Athens, Greece

«

09/2012

5

NMR insights on the functional modulations of the RING domain of Arkadia tumor suppressor.

63 EEBMB

Herakleion/Crete

Greece

«

11/2012

6

Application of NMR in the structural analysis of different domains of Anthrax Lethal Factor metalloprotease

«

«

«

7

Unraveling the conformational plasticity of the extracellular domain of a prokaryotic nAChR homologue in solution by NMR

«

«

«

8

a comparative NMR study of three alphavirus macro domains

«

«

«

9

Expression and NMR analysis of two domains of recombinant La protein from D. discoideum

«

«

«

10

NMR conformational dynamics of Arkadia E3 ubiquitin ligase RING domain.

Turkish NMR Meeting

Istanbul, Turkey


12/2012

11

Preliminary solution NMR studies of three viral macro domains

«

«

«

12

Phase mapping of insulin using Synchrotron X-ray powder diffraction methods” I. Margiolaki

6th HECRA

Athens, Greece

I. Margiolaki & co-workers

09/2012

13

Phase mapping of insulin using Synchrotron X-ray powder diffraction methods

EPDIC 13

Grenoble, France

«

10/2012

14

Electron diffraction as complementary tool to overcome obstacles of structural studies by XRPD

«

I. Margiolaki, & A.S. Galanis

10/2012

15

Investigation of insulin polymorphism via

Synchrotron X-ray Powder Diffraction

«

I. Margiolaki  & co-workers

«

16

Crystallization and Structural Studies of the nsP3 Macro Domain of the Mayaro Virus

«

«

«

17

alpha-“NaLuF4”: 6 fold Twinning with Modulation and Diffuse Scattering

«

«

«

18

Ablation of Geminin in haematopoietic stem cells alters their ability to self-renew and differentiate

4th International Congress on Stem Cells and Tissue Formation,

Dresdner, DE

S. Taraviras & co-workers

07/2012

19

The role of Geminin in the self-renewal and differentiation of hematopoietic stem cells

63rd EEBMB

Herakleion Crete, GR

A. Patmanidi & S. Taraviras

11/2012

20

Selectivity of commonly used pharmacological inhibitors for cystathionine β-synthase (CBS) & cystathionine γ-lyase (CSE)

1st European Conference on the biology of H2S, Smolenice, Slovakia

P. Panopoulos, A. Papapetropoulos

& coworkers

06/2012

21

Effect of mechanical stimulation and carbon nanotube substrate on osteoblast gene expression

5th Conference of Helenic Society of Biomechanics

Thessaloniki, GR

S. Topouzis, V. Kotsikoris & co-workers

09/2012

2013

2013

2013

2013

22

Synchrotron Radiation reveals polymorphism of human insulin crystals

11th ICBSR

Hamburg, Germany

I. Margiolaki & co-workers

09/2013

23

Application of wireless microcurrent electrical stimulation in treatment of complicated wounds: clinical & in vitro studies

EWMA 2013

Copenhagen, Denmark

«

05/2013

24

Wireless Microcurrent Stimulation in treatment of diabetic wounds: clinical & in vitro studies

13th Greek Conference on Diabetes

Athens, Greece

«

05/2013

25

Wireless Microcurrent Stimulation in treatment of diabetic wounds: clinical & in vitro studies

39th Greek Medical Conference

Athens, Greece

«

05/2013

26

Wireless Microcurrent Stimulation in treatment of diabetic wounds: clinical & in vitro studies

BEMS 2013 + BIOEM2013

Thessaloniki, GR

«

06/2013

27

NMR conformational dynamics of Arkadia & Arkadia-2 E3 ubiquitin ligase RING domains.

3rd Bio-NMR Annual User Meeting

Budapest, Hungary

G.A. Spyroulias & co-workers

06/2013

28

a comparative NMR study of four viral macro domains

«

«

«

29

NMR conformational dynamics of Arkadia & Arkadia-2 E3 ubiquitin ligase RING domains.

Euromar 2013

Helakleion, GR

G.A. Spyroulias & co-workers

07/2013

30

NMR insight on the conformational plasticity of the extracellular domain of a prokaryotic nAChR homologue

«

«

«

31

a comparative NMR study of four viral macro domains

«

«

«

32

NMR structural investigation and RNA binding properties of LA protein domains from D. Discoideum

«

«

«

33

Conformational dynamics of N-/C- Terminal domains of Anthrax Lethal Factor metalloprotease

«

«

«

34

UPAT-RISF:

Meeting for the National Greek Roadmap of Research Infrastructures, Athens, GR

«

04/2013

35

Geminin, an inhibitor of DNA replication, regulates self-renewal and commitment decisions in stem cells

Celebrating the 50th anniversary of Replicon Theory, Paris, FR

S. Taraviras & co-workers

03/2013

36

Effect of shear stress, cyclic uniaxial stretch and gravitational unloading on the cytoskeleton and gene expression of bovine capillary endothelial cells.

19th Congress of the European Society of Biomechanics

Patras, GR

S. Topouzis, V. Kotsikoris, & co-workers

08/2013

37

Synchrotron Radiation reveals polymorphism of human insulin crystals

11th International Conference on Biology and Synchrotron Radiation (BSR),

Hamburg, DE

I. Margiolaki & G.A Spyroulias

09/2013

38


26th Meeting of the Hellenic Society for Neuroscience, November 29-December 1, 2013

Nikolopoulou P, Stathopoulou A, Lygerou Z., Taraviras S.

12/2013

39


Structure-Function relationship of mutated forms of ARKADIA E3 Ubiquitin Ligase RING domain

64th EEBMB

Athens, GR

G.A. Spyroulias

& coworkers

12/2013

40


NMR insights on the conformational plasticity of the extracellular domain of a prokaryotic nAChR homologue

64th EEBMB

Athens, GR

G.A. Spyroulias

& coworkers

12/2013

41


NMR conformational dynamics of ARKADIA & ARKADIA-2 E3 Ubiquitin Ligases RING domains

64th EEBMB

Athens, GR

G.A. Spyroulias

& coworkers

12/2013

42


Structural and functional studies on La and RRM1 motifs of an important tRNA-associated chaperone

64th EEBMB

Athens, GR

G.A. Spyroulias

& coworkers

12/2013

2014

2014

2014

2014

43


Chemoimunological study of wireless microcurrent electrical stimulation in treatment of wounds

40th Annual Panhellenic Medical Conference

Athens, GR

K.Poulas, G.Lagoumintzis & coworkers

05/2014

43


Non-contact current transfer in antimacrobial treatement: clinical and in vitro studies

40th Annual Panhellenic Medical Conference

Athens, GR

K.Poulas, M.Kambouris & coworkers

05/2014

44

UPAT-RISF

Meeting for the National Greek Roadmap of Research Infrastructures, Athens, GR

«

06/2014

45


Novel crystalline phase and first order phase transitions of human insulin complexed with phenol-derivatives

EPDIC14 - The European Powder Diffraction Conference

Aarhus, DK

A. Valmas & I. Margiolaki

06/2014

46


Innovative electroceuticals for accelerating trauma recovery and enhancing athletes’ muscle performance

VIth MuscleTech Network Workshop

Barcelona, Spain

G. Lagoumintzis, K. Poulas et al.

11/2014

47


Wireless Microcurrent stimulation technology improves firework burn healing. Clinical applications of WMCS tehnology

MOBIHEALTH 2014, 4th International Conference on Wireless Mobile Communication and Healthcare

G. Lagoumintzis, S. Sideris, M. E. Kambouris

et al.

11/2014

48

The role of hydrogen ulphide in the adherence of endothelial cells in vitro

3rd European Meeting on Hydrogen Sulfide

S. Topouzis & A. Papapetropoulos

05/2015

49


INVESTIGATION OF THE STRUCTURE-ACTIVITY RELATIONSHIP OF e3 UBIQUITIN LIGASES: MUTATIONS OF aRKADIA RING-H2 DOMAIN

4AUM – BIO-NMR Conference

Warsaw, Polland

Marousis K,

Herrmann T, V Episkopou, et al.

05/2014

50


NMR insights on the conformational plasticity of the extracellular domain of a prokaryotic nAChR homologue

Argyriou A., Chasapis CT, Corringer J.-P.

05/2014

51

NMR CONFORMATIONAL DYNAMICS OF La AND RRM1 MOTIFS OF La PROTEIN

FEBS-EMBO 2014,

Paris France

Vourtsis D, Argyriou A., Stathopoulos C et al.

09/2014

52

SOLUTION nmr study of VIRAL macro domains

Tsika A., Ntonti D., Coutard B, Bentrop D, et al.

09/2014

53


NMR conformational dynamics of La protein domains La, RRM1 and RRM2

25th tRNA Conference, Kyllini, Peloponese, Greece

Vourtsis, D.

Et al.

09/2014

54


NMR conformation dynamics of La and RRM1 motifs of La protein

CTSB & HeCrA7

FORTH, Crete Greece

A. Argyriou, C.T. Chasapis, D. Bentrop, G.A.Spyroulias

09/2014

55


NMR insights in the structure-activity relationship of Arcadia E3 ubiquitin ligase

M. Birkou, C.T. Chasapis, D. Bentrop, G.A.Spyroulias

09/2014

56


High yield production of Met(-1)-Angiogenin for Xray crystallography and NMR studies

D. S. Chatzileontiadou, A. Tsika, et al.

09/2014

57


Solution NMR study of viral macro domains

A.C. Tsika, et al.

09/2014

2015

2015

2015

2015

58


ExPRESSION AND STRUCTURAL DETERMINATION OF MAYARO VIRUS MACRO DOMAIN VIA NMR SPECTROSCOPY

16th Hellenic Symposium of Medicinal Chemistry

Tsika A., Spyroulias G.A.et al.

04/2015

59


NMR CONFORMATIONAL DYNAMICS OF LAM, RRM1 AND RRM2 DOMAINS OF La PROTEIN

16th Hellenic Symposium of Medicinal Chemistry

Tsika A., Spyroulias G.A.et al.

04/2015

60


An NMR-DRIVEN STUDY ON THE FUNCTIONAL AND STRUCTURAL ROLE OF THE CONSERVED TRYPTOPHAN IN ARKADIA & ARKADIA-2C RING DOMAINS

16th Hellenic Symposium of Medicinal Chemistry

Giannari D, Chasapis CT, Bentrop D, Episkopou V, Spyroulias G.A.

04/2015

61


SOLUTION NMR STUDY OF VIRAL MACRO DOMAINS

16th Hellenic Symposium of Medicinal Chemistry

Ntonti D, Coutard B, Papageorgiou N, Spyroulias GA

04/2015

62


expression of the N-terminal domain of anthrax lethal factor AND PREDICTION of its secondary structure via nmr analysis

16th Hellenic Symposium of Medicinal Chemistry

Tsika A,

Coutard B, Papageorgiou N, Spyroulias GA

04/2015

63


NMR Applications in Biomedical research, Analytical Chemistry and Diagnostics

Patras IQ

G.A. Spyroulias et al.

04/2015

64


Muscle strain recovery with the aid of pulsed electromagnetic fields in professional football players.

6th Panhellenic Conference on Biomedical Technologies, Athens, Greece

G. Lagoumintzis, K. Poulas et al.

05/2015

65


Combined therapy of Wireless Microcurrent stimulation technology and pulsed electromagnetic fields for chronic wounds

41ο PanHellenic Medical Congress, Athens, Greece

G. Lagoumintzis, K. Poulas et al

06/2015

66


Muscle strain recovery with the use of Wireless Microcurrent stimulation technology in high performance athletes.

G. Lagoumintzis, K. Poulas et al.

06/2015

67


Crystallization of proteins under the influence of microcurrents and electromagnetic fields.

NMR Applications in Life Sciences: Exploring Peptides & Proteins

G. Lagoumintzis, K. Poulas et al.

06/2015

68


Study of the effect of pulsed electromagnetic fields (pemf) in classical swine fever virus polymerase (csfvp) crystallization.

«

06/2015

69


Apoptosis blocking assay: an accurate and quick assay for baculovirus titration.

A. Niarchos, G. Lagoumintzis, K. Poulas et al

06/2015

70


NMR CONFORMATIONAL DYNAMICS OF LAM, RRM1 AND RRM2

DOMAINS OF La PROTEIN

SEEDRUG NMR Applications in Life Sciences – Exploring Peptides & Proteins

Argyriou A., Chasapis CT.,

Bentrop D.,

Spyroulias GA

06/2015

71


NMR study of a soluble Guanylate Cyclase (sGC) human homologue: the HNOX domain from Nostoc sp.

Argyriou A.,

Alexandropoulos I. Papapetropoulos A.

06/2015

72


NMR INSIGHTS ON THE CONFORMATIONAL PLASTICITY OF THE EXTRACELLULAR DOMAIN OF A PROKARYOTIC nAChR HOMOLOGUE

Argyriou A.,

Corringer J.-P.

Et al.

06/2015

73


ATOMIC-LEVEL INSIGHTS ON THE STRUCTURAL AND FUNCTIONAL ROLE OF A CONSERVED TRP RESIDUE IN RING DOMAIN CLASS OF E3 UBIQUITIN LIGASES

Birkou M., Marousis K.,

Herrmann T., et al.

06/2015

74


CLONING, ISOLATION AND EXPRESSION OF THE RING DOMAIN OF RNF11, A ZINC Zn(II) PROTEIN, WITH E3 UBIQUITIN LIGASE ACTION

Bouga M., Argyriou A., et al.

06/2015

75


NMR INSIGHTS ON STRUCTURE OF TWO VIRAL MACRO DOMAINS

Ntonti D., Makrynitsa G,

Coutard B, et al.

06/2015

76


Investigation of the structure-activity relationship of E3 ubiquitin ligases: mutations of Arkadia RING-H2 domain

Maroysis KD, Birkou M, Bentrop D, et al.

06/2015

77


Structure– Activity Relationship study of Mayaro and Chikungunya viruses’ macro domains via solution NMR spectroscopy

Tsika A, Melekis S, Chasapis CT, Coutard B, et al.

06/2015

78


EXPRESSION OF THE N-TERMINAL DOMAIN OF ANTHRAX LETHAL FACTOR AND PREDICTION OF ITS SECONDARY STRUCTURE VIA NMR ANALYSIS

Vourtsis D, Chasapis CT, Bentrop D, et al.

06/2015

79


NMR study of a soluble Guanylate Cyclase (sGC) human homologue: the H-NOX domain from Nostoc sp.

7th International Conference on cGMP

Trier, Germany

A. Argyriou, A. Papapetropoulos, G.A. Spyroulias

06/2015


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  • 01 Jan 2012 Starting data of SEE-DRUG project

  • 23 Feb 2012 Kick-off meeting

  • 23 Apr2012 External Advisory Board meeting

  • 29 Apr 2013 700MHz NMR installed