image image image

“SEE-DRUG ” is a FP7 - RESEARH POTENTIAL project that aims to the upgrade the Structural Biology capacities of UPAT and to the Establishment of a Center of Excellence for Structure-Based Drug Target chracterization efforts in South-Eastern EU region.
Read the Full Story

“SEE-STRUCT” is structure-oriented module of SEE-DRUG project and aims to the structural elucidation of proteins, enzymes and other interesting drug-targets. The tools offered for these efforts are a state-of-the-art high field NMR instrument of 700 MHz equipped with a highly sensitive probe and crystallization robot.
Read the Full Story

“SEE-PROT” & “SEE-PHARM” are the protein production and the preclinical evaluation of molecules, modules of SEE-DRUG project. The tools offered for these efforts are protein production and characterization facilities an upgraded confocal microscope, an intravital microscope and myographs.
Read the Full Story

NMR
700MHz
High sensetivity probe
Studies in solution
Conformation/Dynamics
3D Structure determination, mobility, protein-protein interaction, protein-drug interactions
Confocal
In-cell imaging
Leica Microscope
Tandem Scanner
Additional laser
Sub-cellular ablation in live cells, protein-complexes, protein drug interactions in vivo
Robot
Crystal growth
Automation
Crystalization trials
Fast & efficient
Crystal growth optimization, screen of protein targes in paraller with NRM Spectroscopy
Microscopes
Myographs
intravital Microscope
In vivo
Ex vivo
Drug screening for anti-inflammatory compounds, evaluation of vasoactive compounds

Stuctural Biology
NMR & Xray
2H/13C/15N labeling
Selective labeling
Crystallization
Conformation dynamics, Modeling Structure determination, 3D solutions & crystal models, Bioinformatics
Molecular Biology
Biochemistry
Drug-targets
Biochemical pathways
Protein production
High-yield protein expression, labeling & isolation for structural studies, protein biochemistry
Imaging
In-cell studies
Functional imaging
Light Microscopy
FRET measurements
Studies of biomolecular functions through Advanced Light Microscopy, Sub-cellular ablations
Pharmacology
Inflammation
Vascular Biology
Cell-based assays
Signaling pathways
Monitoring cell processes (migration. proliferation, apoptosis), in vivo & ex vivo assays

Expertise Exchange
Twinnings
Knowledge transfer
Best practices
New applications
Exchange of researchers between UPAT and partnering organizations - EU Centers of excellence
Events
Workshops
Structural Biology
Biochemistry
Imaging
Workshops and scientific meetings will be organized at UPAT, Advanced training course in NMR
Dissemination
Conferences
Biomolecular NMR
Life Sciences
Analysis
Invited talks, Meeting participation & Poster presentations by SEE-DRUG members
Brokerage Events
Info-days
Meet the expers
Links with industry
Regional Authorities
Colloquia with invited speakers from academia or industry and private sector stakeholders

1st EAB Meeting, April 2012

1st EAB Meeting. The first External Advisory Board Meeting was organized at 23rd of April 2012 and participated all the SEEDRUG UPAT’s Consortium members and their teams,

Prof Ivano Bertini (Chair of the EAB) could not join the meeting due to health problems and was replaced by Prof Claudio Luchinat.

Industrial partners of the SEEDRUG project, members of the SME CBL Biopharmaceuticals Patras, (Prof K. Barlos & Prof D. Gatos) and spin-off company ELDRUG SA (Dr. Minos Matsoukas) with oral presentations and/or by taking part at the Round Table discussion.

UPAT’s authorities and Chairman of the Department of Pharmacy welcome addresses the participants.

SEEDRUG Coordinator opened the scientific part of the meeting and presented the work performed in each one of the SEEDRUG’s work packages already and the activity planned for the future (recruitment of the experienced researchers, progress on the research equipment acquisition, planned twinning & networking activities and dissemination activities).

All SEEDRUG consortium members provided an overview of their research plans through SEEDRUG project.

The members of the EAB commented on the progress made during the first 4 months of the project’s duration and on the future project’s plans. Specifically discussion included the following topics:

  • networking activities that already performed or planned.

  •  future SEEDRUG’s research orientation, with a special focus on drug design efforts and the building of a national and an international network to ensure viability of the facility for the years after the end of the SEEDRUG project.

  •  the acquisition and installation at UPAT of modern research instrumentation, which may increase the institutional networking efforts

  •  new NMR-driven initiatives, such as Magnetic Resonance Diagnostics, through NMR metabolomics.

  •  SEEDRUG consortium efforts should be made on the direction of the construction of a viability plan for the SEEDRUG capacities (instrumentation plus personnel).


Industrial SEEDRUG partners (CBL Biopharmaceutical Patras, & ELDRUG SA) participated in the meeting suggesting means and actions towards the establishment of new links between SEEDRUG and industrial partners (through service and preparation of new products).


MONDAY 23rd APRIL 2012

Conference & Cultural Center
University of Patras
Room II-9 (1st Floor)

Chairpersons

Z. Lygerou (Dept of Medicine) & I. Margiolaki (Dept of Biology)

09:30 – 9:45Welcome Addresses - Introduction (The SEE-DRUG project)
University of Patras Authorities &
Georgios A. Spyroulias
09:45 – 10:15

Genomic Databases & personalized medicine
George Patrinos
University of Patras, Department of Pharmacy, Hellas

10:15 – 10:50

Pharmacological control of arterial smooth muscle and endothelial cell phenotype
Stavros Topouzis

University of Patras, Department of Pharmacy, Hellas


10:50 – 11:10
 EAB Member contribution

Arkadia a RING domain E3 ubiquitin ligase, supports the tumor suppressing properties of the TGFbeta pathway
Vasso Episkopou

Imperial College, London, UK

11:10 – 11:45

NMR-based Structure-Activity Correlation Study of Arkadia E3 Ubiquitin Ligase Domain
Georgios A. Spyroulias
University of Patras, Department of Pharmacy, Hellas

11:45 – 12:00Coffee Break
Chairpersons

 G.A. Spyroulias (Dept of Pharmacy) & K. Poulas (Dept of Pharmacy)


12:00 – 12:45
EAB Member contribution

Lightening from NMR in Life Sciences
Ivano Bertini
Center of Magnetic Resonance (CERM), Florence, IT


12:45 – 13:20
SME Member contribution

Studies on the “in vitro oxidative folding” of the A and B chains of the Insulin Like Peptides (INSL)
Kleomenis Barlos
University of Patras & CBL SA Patras, Patras, Hellas

13:20 – 13:40

Factors that modulate the pKa of the attacking thiolate anion of glutaredoxin
Alexios Vlamis
University of Patras, Department of Chemistry, Hellas


13:40 – 14:00
Discussion

SEE-DRUG strategic plan – Suggestions & Comments by EAB members
Ivano Bertini, Vasso Episkopou, Anastassis Perrakis & SEE-DRUG Members

14:00 – 15:30Light lunch & Coffee
Chairpersons

 T. Tselios (Dept of Chemistry) & A. Vlamis (Dept of Chemistry)


15:30 – 16:15
EAB Member contribution

The curious story of J-base and JBP1.
Anastassis Perrakis

National Cancer Institute (NKI), Amsterdam, The Netherlands

16:15 – 16:50

Control of DNA replication in time and space
Zoi Lygerou

University of Patras, Department of Medicine, Hellas

16:50 – 17:10

Peptide-mimetics, a new generation of drugs
John Matsoukas
University of Patras, Department of Chemistry, Hellas

17:10 – 17:30Closing Remarks



Z. Lygerou  (Dept of Medicine)

Upcoming Events

Hot off the Press

porn /div> The NMR Structure of ARKADIA RING Domain (Proteins 2012, 50, 1484-89)

H2S and NO in angiogenesis & vasodilatation (PNAS 2012 in the press)

Site Statistics

mod_vvisit_countermod_vvisit_countermod_vvisit_countermod_vvisit_countermod_vvisit_countermod_vvisit_counter
mod_vvisit_counterToday25
mod_vvisit_counterYesterday43
mod_vvisit_counterThis week118
mod_vvisit_counterLast week401
mod_vvisit_counterThis month970
mod_vvisit_counterLast month1258
mod_vvisit_counterAll days208381

We have: 20 guests, 1 bots online
Your IP: 34.204.0.181
 , 
Today: May 22, 2019
University of Patras General Info, Services, Research Committee, etc.

FP7 Research & Innovation – Participants Portal – Calls for applications

International Meetings & Conferences

Journal Club

  • 01 Jan 2012 Starting data of SEE-DRUG project

  • 23 Feb 2012 Kick-off meeting

  • 23 Apr2012 External Advisory Board meeting

  • 29 Apr 2013 700MHz NMR installed