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“SEE-DRUG ” is a FP7 - RESEARH POTENTIAL project that aims to the upgrade the Structural Biology capacities of UPAT and to the Establishment of a Center of Excellence for Structure-Based Drug Target chracterization efforts in South-Eastern EU region.
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“SEE-STRUCT” is structure-oriented module of SEE-DRUG project and aims to the structural elucidation of proteins, enzymes and other interesting drug-targets. The tools offered for these efforts are a state-of-the-art high field NMR instrument of 700 MHz equipped with a highly sensitive probe and crystallization robot.
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“SEE-PROT” & “SEE-PHARM” are the protein production and the preclinical evaluation of molecules, modules of SEE-DRUG project. The tools offered for these efforts are protein production and characterization facilities an upgraded confocal microscope, an intravital microscope and myographs.
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NMR
700MHz
High sensetivity probe
Studies in solution
Conformation/Dynamics
3D Structure determination, mobility, protein-protein interaction, protein-drug interactions
Confocal
In-cell imaging
Leica Microscope
Tandem Scanner
Additional laser
Sub-cellular ablation in live cells, protein-complexes, protein drug interactions in vivo
Robot
Crystal growth
Automation
Crystalization trials
Fast & efficient
Crystal growth optimization, screen of protein targes in paraller with NRM Spectroscopy
Microscopes
Myographs
intravital Microscope
In vivo
Ex vivo
Drug screening for anti-inflammatory compounds, evaluation of vasoactive compounds

Stuctural Biology
NMR & Xray
2H/13C/15N labeling
Selective labeling
Crystallization
Conformation dynamics, Modeling Structure determination, 3D solutions & crystal models, Bioinformatics
Molecular Biology
Biochemistry
Drug-targets
Biochemical pathways
Protein production
High-yield protein expression, labeling & isolation for structural studies, protein biochemistry
Imaging
In-cell studies
Functional imaging
Light Microscopy
FRET measurements
Studies of biomolecular functions through Advanced Light Microscopy, Sub-cellular ablations
Pharmacology
Inflammation
Vascular Biology
Cell-based assays
Signaling pathways
Monitoring cell processes (migration. proliferation, apoptosis), in vivo & ex vivo assays

Expertise Exchange
Twinnings
Knowledge transfer
Best practices
New applications
Exchange of researchers between UPAT and partnering organizations - EU Centers of excellence
Events
Workshops
Structural Biology
Biochemistry
Imaging
Workshops and scientific meetings will be organized at UPAT, Advanced training course in NMR
Dissemination
Conferences
Biomolecular NMR
Life Sciences
Analysis
Invited talks, Meeting participation & Poster presentations by SEE-DRUG members
Brokerage Events
Info-days
Meet the expers
Links with industry
Regional Authorities
Colloquia with invited speakers from academia or industry and private sector stakeholders

Descritption

The applicant and SEE-DRUG beneficiary, University of Patras (UPAT), is one of Greece’s pre-eminent Education and Research Organizations (founded in 1964) and is characterized by highly-cited research activities in biological and chemical sciences and is considered the premier academic institution in Western Greece (has the largest number of educational/research personnel and students among all Universities of South-Western Greece). Over the last 10 years, UPAT has acted on its long-term vision of expansion and has recruited high quality researchers in modern fields of Life Sciences. These scientists have contributed to the transfer of knowledge from their previous, top-of-the-class, institutions to the UPAT departments, where they apply cutting-edge techniques in the fields of Structural or Chemical Biology and Pharmacology. However, UPAT’s further development is hampered by the lack of certain expensive, modern equipment. Lately, the available UPAT resources and especially the R&D Infrastructures seem increasingly inadequate to support the complete structural and functional characterization of protein drug targets and of lead compounds as potential drugs. Therefore, the integration of investigators from the main axes of structure-based design and evaluation of biological molecules is seriously impaired, and the “brain-gain” process of the last decade shows signs of turning into “brain-drain” in these areas of research and development. In essence, there are significant missing links in the chain: basic research  applied research  public health that could otherwise contribute to the regional scientific and economical growth. We firmly believe that this state of affairs is reversible, and that the SEE-DRUG project will be an important step in overturning this situation.

SEE-DRUG is a joint project from a number of groups working in various disciplines of basic and applied sciences: chemists, pharmacologists, biologists and bioinformaticians, affiliated to the Departments of Biology, Chemistry, Medicine and Pharmacy, supported also by the UPAT-affiliated distinct entity, the “Centre of Instrument-based Analysis”.

The SEE-DRUG strategy is essentially based on four core activities: Exchange of technological know-how and scientific expertise, Appointment of experienced, skilled researchers, Upgrading of the UPAT S&T Infrastructure and Organization of Workshops and Conferences.


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  • 01 Jan 2012 Starting data of SEE-DRUG project

  • 23 Feb 2012 Kick-off meeting

  • 23 Apr2012 External Advisory Board meeting

  • 29 Apr 2013 700MHz NMR installed