“SEE-DRUG ” is a FP7 - RESEARH POTENTIAL project that aims to the upgrade the Structural Biology capacities of UPAT and to the Establishment of a Center of Excellence for Structure-Based Drug Target chracterization efforts in South-Eastern EU region.
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“SEE-STRUCT” is structure-oriented module of SEE-DRUG project and aims to the structural elucidation of proteins, enzymes and other interesting drug-targets. The tools offered for these efforts are a state-of-the-art high field NMR instrument of 700 MHz equipped with a highly sensitive probe and crystallization robot. Read the Full Story
“SEE-PROT” & “SEE-PHARM” are the protein production and the preclinical evaluation of molecules, modules of SEE-DRUG project. The tools offered for these efforts are protein production and characterization facilities an upgraded confocal microscope, an intravital microscope and myographs. Read the Full Story
- 1Research Facilities
- 2Scientific Expertise
- 3Networking & Dissemination
Objectives
The overall strategic objective of the current proposal aim to strengthen and broaden the scientific reach and socio-economic impact of the University of Patras (UPAT) through the creation of a Regional Centre of Excellence for Structural Biology that emphasizes the characterization and development of bioactive molecules with therapeutic potential.This will be accomplished by the establishment of a multi-disciplinary platform of high-level scientific research that focuses on the development of bioactive molecules targeting important biochemical processes in cancer, cardiovascular and neurodegenerative diseases.
The above targets will be achieved when the existed S&T Infrastructures and expertise (Figure 1) can be integrated in a unique scientific platform in Greece and SouthEastern EU region consisting of the following modules:
● SEE-PROT: Production of protein & peptides and screening/optimization of polypeptide samples, for structural and functional studies either by NMR or by X-ray and other biophysical techniques. NMR will be used to screen polypeptide samples to be used for solid-state conformational analysis, and will significantly increase the success rates of proposal applications for access to high-cost Large RIs for X-ray & High-Field NMR studies.
● SEE-STRUCT: Conformational dynamics, interactions & biophysical characterization, to provide atomic-level insight on individual proteins and protein-protein/drug candidates interaction, to identify new protein-protein interactions and to investigate the physicochemical properties (dynamics, affinity, kinetics, etc) of these interactions, based on NMR methods, automated crystallization and other complementary techniques.
● SEE-PHARM: Disease-modelling cell-based assays including live cell imaging techniques, complemented by ex vivo and in vivo screening, to test protein-protein/peptide and protein-drug lead interactions, evaluate efficacy of candidate molecules, determine new biomolecular interactions and study the effects of the leads on basic cellular pathways. SEE-PHARM’s role will therefore be to use all its available tools to test bio-molecules developed on NMR structure-based information and provide valuable feedback regarding their optimization
Upcoming Events
- 2nd EAB Meeting 13th May 2013
- 2nd SEE-DRUG Workshop - NMR Basics & Applications in Life Sciences, May 13-15, 2013
- 1st EAB Meeting, 23 April, 2012
- 1st SEE-DRUG Workshop - From Chemical to Systems Biology, 9-10 May, 2012
- A list with Scientific Events, April-May 2012
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Today: Apr 23, 2024
- 01 Jan 2012 Starting data of SEE-DRUG project
- 23 Feb 2012 Kick-off meeting
- 23 Apr2012 External Advisory Board meeting
- 29 Apr 2013 700MHz NMR installed