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“SEE-DRUG ” is a FP7 - RESEARH POTENTIAL project that aims to the upgrade the Structural Biology capacities of UPAT and to the Establishment of a Center of Excellence for Structure-Based Drug Target chracterization efforts in South-Eastern EU region.
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“SEE-STRUCT” is structure-oriented module of SEE-DRUG project and aims to the structural elucidation of proteins, enzymes and other interesting drug-targets. The tools offered for these efforts are a state-of-the-art high field NMR instrument of 700 MHz equipped with a highly sensitive probe and crystallization robot.
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“SEE-PROT” & “SEE-PHARM” are the protein production and the preclinical evaluation of molecules, modules of SEE-DRUG project. The tools offered for these efforts are protein production and characterization facilities an upgraded confocal microscope, an intravital microscope and myographs.
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NMR
700MHz
High sensetivity probe
Studies in solution
Conformation/Dynamics
3D Structure determination, mobility, protein-protein interaction, protein-drug interactions
Confocal
In-cell imaging
Leica Microscope
Tandem Scanner
Additional laser
Sub-cellular ablation in live cells, protein-complexes, protein drug interactions in vivo
Robot
Crystal growth
Automation
Crystalization trials
Fast & efficient
Crystal growth optimization, screen of protein targes in paraller with NRM Spectroscopy
Microscopes
Myographs
intravital Microscope
In vivo
Ex vivo
Drug screening for anti-inflammatory compounds, evaluation of vasoactive compounds

Stuctural Biology
NMR & Xray
2H/13C/15N labeling
Selective labeling
Crystallization
Conformation dynamics, Modeling Structure determination, 3D solutions & crystal models, Bioinformatics
Molecular Biology
Biochemistry
Drug-targets
Biochemical pathways
Protein production
High-yield protein expression, labeling & isolation for structural studies, protein biochemistry
Imaging
In-cell studies
Functional imaging
Light Microscopy
FRET measurements
Studies of biomolecular functions through Advanced Light Microscopy, Sub-cellular ablations
Pharmacology
Inflammation
Vascular Biology
Cell-based assays
Signaling pathways
Monitoring cell processes (migration. proliferation, apoptosis), in vivo & ex vivo assays

Expertise Exchange
Twinnings
Knowledge transfer
Best practices
New applications
Exchange of researchers between UPAT and partnering organizations - EU Centers of excellence
Events
Workshops
Structural Biology
Biochemistry
Imaging
Workshops and scientific meetings will be organized at UPAT, Advanced training course in NMR
Dissemination
Conferences
Biomolecular NMR
Life Sciences
Analysis
Invited talks, Meeting participation & Poster presentations by SEE-DRUG members
Brokerage Events
Info-days
Meet the expers
Links with industry
Regional Authorities
Colloquia with invited speakers from academia or industry and private sector stakeholders

Objectives

The overall strategic objective of the current proposal aim to strengthen and broaden the scientific reach and socio-economic impact of the University of Patras (UPAT) through the creation of a Regional Centre of Excellence for Structural Biology that emphasizes the characterization and development of bioactive molecules with therapeutic potential.This will be accomplished by the establishment of a multi-disciplinary platform of high-level scientific research that focuses on the development of bioactive molecules targeting important biochemical processes in cancer, cardiovascular and neurodegenerative diseases.

The above targets will be achieved when the existed S&T Infrastructures and expertise (Figure 1) can be integrated in a unique scientific platform in Greece and SouthEastern EU region consisting of the following modules:

SEE-PROT: Production of protein & peptides and screening/optimization of polypeptide samples, for structural and functional studies either by NMR or by X-ray and other biophysical techniques. NMR will be used to screen polypeptide samples to be used for solid-state conformational analysis, and will significantly increase the success rates of proposal applications for access to high-cost Large RIs for X-ray & High-Field NMR studies.

SEE-STRUCT: Conformational dynamics, interactions & biophysical characterization, to provide atomic-level insight on individual proteins and protein-protein/drug candidates interaction, to identify new protein-protein interactions and to investigate the physicochemical properties (dynamics, affinity, kinetics, etc) of these interactions, based on NMR methods, automated crystallization and other complementary techniques.

SEE-PHARM: Disease-modelling cell-based assays including live cell imaging techniques, complemented by ex vivo and in vivo screening, to test protein-protein/peptide and protein-drug lead interactions, evaluate efficacy of candidate molecules, determine new biomolecular interactions and study the effects of the leads on basic cellular pathways. SEE-PHARM’s role will therefore be to use all its available tools to test bio-molecules developed on NMR structure-based information and provide valuable feedback regarding their optimization


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  • 01 Jan 2012 Starting data of SEE-DRUG project

  • 23 Feb 2012 Kick-off meeting

  • 23 Apr2012 External Advisory Board meeting

  • 29 Apr 2013 700MHz NMR installed