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“SEE-DRUG ” is a FP7 - RESEARH POTENTIAL project that aims to the upgrade the Structural Biology capacities of UPAT and to the Establishment of a Center of Excellence for Structure-Based Drug Target chracterization efforts in South-Eastern EU region.
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“SEE-STRUCT” is structure-oriented module of SEE-DRUG project and aims to the structural elucidation of proteins, enzymes and other interesting drug-targets. The tools offered for these efforts are a state-of-the-art high field NMR instrument of 700 MHz equipped with a highly sensitive probe and crystallization robot.
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“SEE-PROT” & “SEE-PHARM” are the protein production and the preclinical evaluation of molecules, modules of SEE-DRUG project. The tools offered for these efforts are protein production and characterization facilities an upgraded confocal microscope, an intravital microscope and myographs.
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High sensetivity probe
Studies in solution
3D Structure determination, mobility, protein-protein interaction, protein-drug interactions
In-cell imaging
Leica Microscope
Tandem Scanner
Additional laser
Sub-cellular ablation in live cells, protein-complexes, protein drug interactions in vivo
Crystal growth
Crystalization trials
Fast & efficient
Crystal growth optimization, screen of protein targes in paraller with NRM Spectroscopy
intravital Microscope
In vivo
Ex vivo
Drug screening for anti-inflammatory compounds, evaluation of vasoactive compounds

Stuctural Biology
NMR & Xray
2H/13C/15N labeling
Selective labeling
Conformation dynamics, Modeling Structure determination, 3D solutions & crystal models, Bioinformatics
Molecular Biology
Biochemical pathways
Protein production
High-yield protein expression, labeling & isolation for structural studies, protein biochemistry
In-cell studies
Functional imaging
Light Microscopy
FRET measurements
Studies of biomolecular functions through Advanced Light Microscopy, Sub-cellular ablations
Vascular Biology
Cell-based assays
Signaling pathways
Monitoring cell processes (migration. proliferation, apoptosis), in vivo & ex vivo assays

Expertise Exchange
Knowledge transfer
Best practices
New applications
Exchange of researchers between UPAT and partnering organizations - EU Centers of excellence
Structural Biology
Workshops and scientific meetings will be organized at UPAT, Advanced training course in NMR
Biomolecular NMR
Life Sciences
Invited talks, Meeting participation & Poster presentations by SEE-DRUG members
Brokerage Events
Meet the expers
Links with industry
Regional Authorities
Colloquia with invited speakers from academia or industry and private sector stakeholders


Department of Pharmacy

  • Dr. Georgios A. Spyroulias, Biomolecular NMR Spectroscopy, Protein production, labeling (uniform or selective/specific) & biophysical characterisation, Structural Biology, Biomolecular Simulations.
  • Dr. Konstantinos Poulas, Protein production & characterisation, X-ray Crystallography, Molecular modelling and Bioinformatics.
  • Dr. George P. Patrinos, Human genomics, pharmacogenomics, Bioinformatics and genetic databases.
  • Prof. Andreas Papapetropoulos, Cellular Signalling, Protein-Protein Interactions, Cardiovascular Pharmacology, Inflammation, Pre-clinical drug screening & Development.
  • Dr. StavrosTopouzis, Use of preclinical, cell-based (in vitro) and animal-based (in vivo) models, for the study of human fibroproliferative and inflammatory diseases.

Department of Medicine

  • Nicholas Moschonas, Protein production in bacteria and animal cells, gene expression and functional analysis of proteins, in vitro and cell-based assessment of protein-protein interactions.
  • Zoi Lygerou, Functional imaging, protein analysis in human cells and yeast, systems biology.
  • Stavros Taraviras, Generation and analysis of genetically modified mice, isolation and culturing of embryonic haematopoietic and neural stem/progenitor cells, biochemical characterisation of protein complexes, determination of gene and protein expression, live-cell imaging techniques.

Department of Chemistry

  • John Matsoukas, Organic, Peptide synthesis and Characterization of Bioactive Molecules, Structure-Activity Relationship Studies.
  • Theodore Tselios, Rational Design, Synthesis & Characterization of Bioactive Molecules, Biomolecular and Docking Simulations.
  • Alexios Vlamis-Gardikas, Overexpression and purification of recombinant proteins, protein-protein interaction analysis, bacterial genetics, molecular biology, enzyme assays (especially those related to antioxidant enzymes).

Department of Biology

  • Kostas Flytzanis, Gene regulation in early embryonic development of the sea urchin Paracentrotus lividus, study of the transcription factors and SAR studies on nuclear receptors (e.g. COUP-TF; Chicken Ovalbumin Upstream Promoter–Transcription Factors).
  • Irene Margiolaki, Method development and application of Crystallography & Structural Biology. Extensive knowledge of powder and single crystal diffraction, structure determination, model building, refinement, and skills in Small Angle X-ray Scattering, optical/electron microscopy etc.

Upcoming Events

Hot off the Press

porn /div> The NMR Structure of ARKADIA RING Domain (Proteins 2012, 50, 1484-89)

H2S and NO in angiogenesis & vasodilatation (PNAS 2012 in the press)

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  • 01 Jan 2012 Starting data of SEE-DRUG project

  • 23 Feb 2012 Kick-off meeting

  • 23 Apr2012 External Advisory Board meeting

  • 29 Apr 2013 700MHz NMR installed