“SEE-DRUG ” is a FP7 - RESEARH POTENTIAL project that aims to the upgrade the Structural Biology capacities of UPAT and to the Establishment of a Center of Excellence for Structure-Based Drug Target chracterization efforts in South-Eastern EU region. Read the Full Story
“SEE-STRUCT” is structure-oriented module of SEE-DRUG project and aims to the structural elucidation of proteins, enzymes and other interesting drug-targets. The tools offered for these efforts are a state-of-the-art high field NMR instrument of 700 MHz equipped with a highly sensitive probe and crystallization robot. Read the Full Story
“SEE-PROT” & “SEE-PHARM” are the protein production and the preclinical evaluation of molecules, modules of SEE-DRUG project. The tools offered for these efforts are protein production and characterization facilities an upgraded confocal microscope, an intravital microscope and myographs. Read the Full Story
1Research Facilities
2Scientific Expertise
3Networking & Dissemination
NMR
700MHz
High sensetivity probe
Studies in solution
Conformation/Dynamics
3D Structure determination, mobility, protein-protein interaction, protein-drug interactions
Dr. Georgios A. Spyroulias, Biomolecular NMR Spectroscopy, Protein production, labeling (uniform or selective/specific) & biophysical characterisation, Structural Biology, Biomolecular Simulations.
Dr. Konstantinos Poulas, Protein production & characterisation, X-ray Crystallography, Molecular modelling and Bioinformatics.
Dr. George P. Patrinos, Human genomics, pharmacogenomics, Bioinformatics and genetic databases.
Prof. Andreas Papapetropoulos, Cellular Signalling, Protein-Protein Interactions, Cardiovascular Pharmacology, Inflammation, Pre-clinical drug screening & Development.
Dr. StavrosTopouzis, Use of preclinical, cell-based (in vitro) and animal-based (in vivo) models, for the study of human fibroproliferative and inflammatory diseases.
Nicholas Moschonas, Protein production in bacteria and animal cells, gene expression and functional analysis of proteins, in vitro and cell-based assessment of protein-protein interactions.
Zoi Lygerou, Functional imaging, protein analysis in human cells and yeast, systems biology.
Stavros Taraviras, Generation and analysis of genetically modified mice, isolation and culturing of embryonic haematopoietic and neural stem/progenitor cells, biochemical characterisation of protein complexes, determination of gene and protein expression, live-cell imaging techniques.
John Matsoukas, Organic, Peptide synthesis and Characterization of Bioactive Molecules, Structure-Activity Relationship Studies.
Theodore Tselios, Rational Design, Synthesis & Characterization of Bioactive Molecules, Biomolecular and Docking Simulations.
Alexios Vlamis-Gardikas, Overexpression and purification of recombinant proteins, protein-protein interaction analysis, bacterial genetics, molecular biology, enzyme assays (especially those related to antioxidant enzymes).
Kostas Flytzanis, Gene regulation in early embryonic development of the sea urchin Paracentrotus lividus, study of the transcription factors and SAR studies on nuclear receptors (e.g. COUP-TF; Chicken Ovalbumin Upstream Promoter–Transcription Factors).
Irene Margiolaki, Method development and application of Crystallography & Structural Biology. Extensive knowledge of powder and single crystal diffraction, structure determination, model building, refinement, and skills in Small Angle X-ray Scattering, optical/electron microscopy etc.
Upcoming Events
2nd EAB Meeting 13th May 2013
2nd SEE-DRUG Workshop - NMR Basics & Applications in Life Sciences, May 13-15, 2013