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“SEE-DRUG ” is a FP7 - RESEARH POTENTIAL project that aims to the upgrade the Structural Biology capacities of UPAT and to the Establishment of a Center of Excellence for Structure-Based Drug Target chracterization efforts in South-Eastern EU region.
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“SEE-STRUCT” is structure-oriented module of SEE-DRUG project and aims to the structural elucidation of proteins, enzymes and other interesting drug-targets. The tools offered for these efforts are a state-of-the-art high field NMR instrument of 700 MHz equipped with a highly sensitive probe and crystallization robot.
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“SEE-PROT” & “SEE-PHARM” are the protein production and the preclinical evaluation of molecules, modules of SEE-DRUG project. The tools offered for these efforts are protein production and characterization facilities an upgraded confocal microscope, an intravital microscope and myographs.
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High sensetivity probe
Studies in solution
3D Structure determination, mobility, protein-protein interaction, protein-drug interactions
In-cell imaging
Leica Microscope
Tandem Scanner
Additional laser
Sub-cellular ablation in live cells, protein-complexes, protein drug interactions in vivo
Crystal growth
Crystalization trials
Fast & efficient
Crystal growth optimization, screen of protein targes in paraller with NRM Spectroscopy
intravital Microscope
In vivo
Ex vivo
Drug screening for anti-inflammatory compounds, evaluation of vasoactive compounds

Stuctural Biology
NMR & Xray
2H/13C/15N labeling
Selective labeling
Conformation dynamics, Modeling Structure determination, 3D solutions & crystal models, Bioinformatics
Molecular Biology
Biochemical pathways
Protein production
High-yield protein expression, labeling & isolation for structural studies, protein biochemistry
In-cell studies
Functional imaging
Light Microscopy
FRET measurements
Studies of biomolecular functions through Advanced Light Microscopy, Sub-cellular ablations
Vascular Biology
Cell-based assays
Signaling pathways
Monitoring cell processes (migration. proliferation, apoptosis), in vivo & ex vivo assays

Expertise Exchange
Knowledge transfer
Best practices
New applications
Exchange of researchers between UPAT and partnering organizations - EU Centers of excellence
Structural Biology
Workshops and scientific meetings will be organized at UPAT, Advanced training course in NMR
Biomolecular NMR
Life Sciences
Invited talks, Meeting participation & Poster presentations by SEE-DRUG members
Brokerage Events
Meet the expers
Links with industry
Regional Authorities
Colloquia with invited speakers from academia or industry and private sector stakeholders

EAB & Partners

External Advisory Board

The composition of the External Advisory Board (EAB) is the following:

Prof. Ivano Bertini, Center of Magnetic Resonance, University of Florence, Italy

Prof. Philippe Bastiaens, Max Planck Institute of Molecular Physiology, Dortmund, Germany

Prof. Vasso Episkopou, Imperial College, Faculty of Medicine, MRC CSC, London, UK

Prof. Werner Muller-Esterl, President of the J. W. Goethe University, Frankfurt, Germany

Dr. Anastsassis Perrakis, The Netherlands Cancer Institute, Amsterdam, The Netherlands

Partnering Organizations & Experienced Scientists

(a) Center of Magnetic Resonance (CERM), Florence, ITALY - Prof. Ivano Bertini

(b) Max-Planck-Institute of Molecular Physiology, Dortmund, GERMANY - Prof. Philippe Bastiaens

(c) Imperial College, Faculty of Medicine, London, UNITED KINGDOM - Prof. Vasso Episkopou

(d) Institute of Biochemistry II, Goethe University, Frankfurt, GERMANY - Prof. Werner Mueller-Esterl

(e) The Netherlands Cancer Institute (NKI), Amsterdam, THE NETHERLANDS – Dr. Anastassis Perrakis

(f) Center for Neurogenomics and Cognitive Research (CNCR), Amsterdam, THE NETHERLANDS - Prof. Guus Smit

(g) European Synchrotron Radiation Facility (ESRF), Grenoble, FRANCE - Prof. Andrew Fitch

(h) Center for Biomolecular Magnetic Resonance (BMRZ), University of Frankfurt, Frankfurt, GERMANY - Prof. Harald Schwalbe

(i) Tubitak Marmara Research Center, Food Institute, Instabul, TURKEY – Dr. Somer Bekiroglu

Industrial Partnerships

(a) VIANEX S.A., Pharmaceutical Manufacturers, Greece

(b) CBL (Chemical and Biopharmaceutical Laboratories) Patras, Achaia, Greece.

(c) EL-DRUG, Scientific Park, Patras, Greece.


Upcoming Events

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  • 01 Jan 2012 Starting data of SEE-DRUG project

  • 23 Feb 2012 Kick-off meeting

  • 23 Apr2012 External Advisory Board meeting

  • 29 Apr 2013 700MHz NMR installed