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“SEE-DRUG ” is a FP7 - RESEARH POTENTIAL project that aims to the upgrade the Structural Biology capacities of UPAT and to the Establishment of a Center of Excellence for Structure-Based Drug Target chracterization efforts in South-Eastern EU region.
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“SEE-STRUCT” is structure-oriented module of SEE-DRUG project and aims to the structural elucidation of proteins, enzymes and other interesting drug-targets. The tools offered for these efforts are a state-of-the-art high field NMR instrument of 700 MHz equipped with a highly sensitive probe and crystallization robot.
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“SEE-PROT” & “SEE-PHARM” are the protein production and the preclinical evaluation of molecules, modules of SEE-DRUG project. The tools offered for these efforts are protein production and characterization facilities an upgraded confocal microscope, an intravital microscope and myographs.
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NMR
700MHz
High sensetivity probe
Studies in solution
Conformation/Dynamics
3D Structure determination, mobility, protein-protein interaction, protein-drug interactions
Confocal
In-cell imaging
Leica Microscope
Tandem Scanner
Additional laser
Sub-cellular ablation in live cells, protein-complexes, protein drug interactions in vivo
Robot
Crystal growth
Automation
Crystalization trials
Fast & efficient
Crystal growth optimization, screen of protein targes in paraller with NRM Spectroscopy
Microscopes
Myographs
intravital Microscope
In vivo
Ex vivo
Drug screening for anti-inflammatory compounds, evaluation of vasoactive compounds

Stuctural Biology
NMR & Xray
2H/13C/15N labeling
Selective labeling
Crystallization
Conformation dynamics, Modeling Structure determination, 3D solutions & crystal models, Bioinformatics
Molecular Biology
Biochemistry
Drug-targets
Biochemical pathways
Protein production
High-yield protein expression, labeling & isolation for structural studies, protein biochemistry
Imaging
In-cell studies
Functional imaging
Light Microscopy
FRET measurements
Studies of biomolecular functions through Advanced Light Microscopy, Sub-cellular ablations
Pharmacology
Inflammation
Vascular Biology
Cell-based assays
Signaling pathways
Monitoring cell processes (migration. proliferation, apoptosis), in vivo & ex vivo assays

Expertise Exchange
Twinnings
Knowledge transfer
Best practices
New applications
Exchange of researchers between UPAT and partnering organizations - EU Centers of excellence
Events
Workshops
Structural Biology
Biochemistry
Imaging
Workshops and scientific meetings will be organized at UPAT, Advanced training course in NMR
Dissemination
Conferences
Biomolecular NMR
Life Sciences
Analysis
Invited talks, Meeting participation & Poster presentations by SEE-DRUG members
Brokerage Events
Info-days
Meet the expers
Links with industry
Regional Authorities
Colloquia with invited speakers from academia or industry and private sector stakeholders

Conference

NMR Applications in Life Sciences
Exploring Peptides & Proteins-A Tribute to Paul Cordopatis

17-20 June 2015
Conference & Cultural Center of the University of Patras
Patras-Greece

This International Conference aims to bring together chemistry, molecular and structural biology and pharmacology and disclose the potential use of NMR in tackling important structure and functional issues of biological systems. The update of the biochemists’, biologists’ and pharmacologists’ community on latest achievements in peptide science, protein production & labeling, and the presentation of NMR structural biology applications is a specific aim of this conference.

In addition, in the context of the conference, we will pay tribute to the late Emeritus Professor Paul Cordopatis for his lifelong contribution and dedication to peptide science and the University of Patras.

Topics:

  • New trends and applications in Biomolecular NMR & Structural Biology
  • Peptide synthesis, protein production and labeling for NMR Structural Biology
  • Bio NMR and Complementary techniques
  • NMR-based Metabolomics
  • Mechanistic Systems biology
  • In cell NMR
  • Solid state NMR
  • Peptide Chemistry
  • Bioactive Peptides



Opening Lecture:Kurt Wuthrich(ETH, Zurich, CH  & The SCRIPPS, La Jolla, USA)
Invited Speakers:Frederic Allain        
Umit Akbey                
David Andreu
Kleomenis Barlos          
Somer Bekiroglou    
Rolf Boelens            
John Christodoulou
Isabella Felli        
David Fushman            
Torsten Herrmann    
Ferenc Hudecz         
Babis Kalodimos        
MichaeL Kokkinidis
George Kokotos
Akis Liokatis
Claudio Luchinat
Theodosia Maina  
Jean Martinez
Evangelos Moudrianakis
Michael Orfanopoulos
Hartmut Oschkinat    
Tassos Perrakis        
Kyriacos Petratos
Janez Plavec            
Miquel Pons                
Harald Schwalbe
Nikolaos Sgourakis
Kostas Tripsianes      
Paola Turano            
Giannis Vakonakis   
(Zurich, CH)         
(Berlin, DE)             
(Barcelona, ES)
(Patras, GR)       
(Istanbul, TR)             
(Utrecht, NL)             
(London, UK)                          
(Florence, IT)            
(Maryland, USA)           
(Lyon, FR)                
(Budapest, HU)       
(New Jersey, USA)         
(Heraklion, GR)
(Athens, GR)
(Berlin, DE)
(Florence, IT)
(Athens, GR)        
(Montpellier, FR)
 (Baltimore, USA)
(Heraklion, GR)
(Berlin, DE)              
(Amsterdam, NL)           
(Heraklion, GR)            
(Ljubljana, SI)           
(Barcelona, ES)           
(Frankfurt, DE)
(California, USA)
(Brno, CZ)
(Florence, IT)            
(Oxford, UK)  

Travel Grants (including accommodation) will be available for a small number of young researchers

Abstract submission deadline: May 31, 2015

Organizing Committee

George A. Spyroulias, Chairman

Members: Manolis Fousteris, Fotini N. Lamari, Vassiliki Magafa, Nikos Moschonas, Sotirios Nikolaropoulos, George Pairas, Stavros Topouzis, Theodore Tselios

Abstract submission guidelines (More info about abstract submission will be available soon)

Travel Information from Athens Airport to Patras

Upcoming Events

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University of Patras General Info, Services, Research Committee, etc.

FP7 Research & Innovation – Participants Portal – Calls for applications

International Meetings & Conferences

Journal Club

  • 01 Jan 2012 Starting data of SEE-DRUG project

  • 23 Feb 2012 Kick-off meeting

  • 23 Apr2012 External Advisory Board meeting

  • 29 Apr 2013 700MHz NMR installed