Thursday, 22 December 2011 13:52
Last Updated on Friday, 23 December 2011 13:09
Written by Administrator
The 13 UPAT Faculty members that participate in SEE-DRUG are affiliated with the Departments of Pharmacy, Medicine, Chemistry and Biology. They combine a publication record comprised of 650 publications, 25 published patents and >14000 citations.
Department of Pharmacy
- Dr. Georgios A. Spyroulias, Assoc Prof. Expertise: NMR Spectroscopy, Protein production & characterisation, Structural Biology, Biomolecular Simulations.
- Dr. Konstantinos Poulas, Assist. Prof. Expertise: Protein production & characterisation, X-ray Crystallography, Molecular modelling and Bioinformatics.
- Dr. George P. Patrinos, Assist. Prof. Expertise: Human genomics, pharmacogenomics, Bioinformatics and genetic databases.
Recent publications
- Borg J, Georgitsi M, Patrinos GP, Philipsen S et al. Nature Genet 42, 801-5 (2010)
- Dalkas GA, Chassapis C, Spyroulias GA et al. Biochemistry 49, 10767-9 (2010)
- Georgitsi M, Poulas K, Tzimas G, Patrinos GP et al. Nucleic Acids Res 39(Database issue), D926-32 (2011)
- Abriata LA, Banci L, Bertini I, Gkazonis P, Spyroulias GA, et al. Nature Chem Biol 4, 599, (2008)
- Chen Z, Luo HY, Patrinos GP, et al. Mol Cell Biol 28, 4386-93, (2008)
- Banci L, Kandias NG, Robinson NJ, Spyroulias GA, et al. Proc Natl Acad Sci USA 103, 8320, (2006)
- Prof. Andreas Papapetropoulos, , Prof. Expertise: Cellular Signalling, Protein-Protein Interactions, Cardiovascular Pharmacology, Inflammation, Pre-clinical drug screening & Development
- Dr. StavrosTopouzis, Assist. Prof. Expertise: use of preclinical, cell-based (in vitro) and animal-based (in vivo) models, for the study of human fibroproliferative and inflammatory diseases.
Recent publications
- Papapetropoulos A, Pyriochou A, Altaany Z, Yang G, Marazioti A et al. Proc Natl Acad Sci USA 106:21972-7 (2009)
- Zhou, A. Pyriochou, A. Kotanidou, G. Dalkas, M.V. Eickels, G. Spyroulias, C. Roussos C and Papapetropoulos A. Am J Physiol Heart Circ Physiol. 295:H1763-71 (2008)
- G. Haramis, Z. Zhou, A. Pyriochou, M. Koutsilieris, C. Roussos and A. Papapetropoulos. Br J Pharmacol. 155:804-13 (2008)
- Z. Zhou, S. Gross, C. Roussos, S Meurer, W. Müller-Esterl and A. Papapetropoulos. J. Biol. Chem. 279:24935-24943, (2004)
- Dillon SR, Topouzis S et al. Nature Immunol, 5, 752-760 (2004)
- Papapetropoulos A, Zhou Z, Gerassimou C, Yetik G, Venema RC, Roussos C, et al. Mol Pharmacol. 68:1133-41 (2005)
Department of Medicine
- Nicholas Moschonas, Prof. in Biology & Medical Molecular Genetics, expertise: protein production in bacteria and animal cells, gene expression and functional analysis of proteins, in vitro and cell-based assessment of protein-protein interactions
- Zoi Lygerou, Assistant Professor in Biology, expertise: functional imaging, protein analysis in human cells and yeast, systems biology
Recent publications
- De Marco V, Lygerou Z, Taraviras S, Perrakis A. et al. Proc Natl Acad Sci USA, 106:19807-12 (2009)
- Lygeros J, Nurse P, Lygerou Z. et al. Proc Natl Acad Sci USA, 105:12295-12300 (2008)
- G. Xouri, Taraviras S, Bastiaens PIH, Lygerou Z. et al. EMBO J, 26:1303-1314 (2007)
- P. Deloukas, M. Kokkinaki, T. Sarafidou, N. K. Moschonas et al. Nature, 429, 375-381 (2004)
- H. Nishitani, Z. Lygerou, T. Nishimoto, P. Nurse. Nature 404:625-8 (2000)
- Z. Lygerou, P. Nurse P Science 290:2271-3 (2000)
- Stavros Taraviras, Assistant Professor in Molecular and Cellular Pharmacology, Expertise: generation and analysis of genetically modified mice, isolation and culturing of embryonic haematopoietic and neural stem/progenitor cells, protein expression in different systems, biochemical characterisation of protein complexes, determination of gene and protein expression, live-cell imaging techniques.
Recent publications
- Karamitros D, Kioussis D, Taraviras S et al. J Immunol 184:2432-41 (2010)
- De Marco V, Lygerou Z, Taraviras S, Perrakis A. et al. Proc Natl Acad Sci USA 106:19807-12 (2009)
- Lygerou Z, Taraviras S, Papavassiliou AG, et al. Cancer Res. 67:10899-909 (2007)
- Roukos V, Taraviras S, Lygerou Z et al. J. Biol. Chem, 282:9346-9357 (2007)
- G. Xouri, Taraviras S, Bastiaens PIH, Lygerou Z. et al. EMBO J, 26:1303-1314 (2007)
- Bravou V, Taraviras S, et al. J Pathol. 208:91-9 (2006)
Department of Chemistry
- John Matsoukas, Professor in Organic Chemistry. Expertise: Organic, Peptide synthesis and Characterization of Bioactive Molecules, Structure-Activity Relationship Studies.
- Theodore Tselios, Assistant Professor in Organic Chemistry. Expertise: Rational Design, Synthesis & Characterization of Bioactive Molecules, Biomolecular and Docking Simulations.
- Alexios Vlamis-Gardikas, Assistant Professor in Biochemistry, is a recently appointed faculty member. Expertise: Overexpression and purification of recombinant proteins, protein-protein interaction analysis, bacterial genetics, molecular biology, enzyme assays (especially those related to antioxidant enzymes).
Recent publications
- Katsara M, Tselios T, Matsoukas J, Apostolopoulos V et al. J Med Chem. 52:214-8 (2009).
- Deraos G, Tselios T, Apostolopoulos V, Matsoukas J. et al. J Med Chem. 51:7834-4 (2008).
- Spyranti Z, Matsoukas JM, Tselios TV et al. J Med Chem. 50:6039-47 (2007).
- Keramida MK, Tselios T, Matsoukas J. et al. J Med Chem. 49:105-10 (2006).
- Fernandes AP, Vlamis-Gardikas A. et al J Biol Chem. 280:24544-52 (2005).
- Fladvad M, Vlamis-Gardikas A, Sunnerhagen M et al. J Biol Chem. 280:24553-61 (2005).
Department of Biology
- Kostas Flytzanis, Assoc. Prof. in Cell Biology expertise: gene regulation in early embryonic development of the sea urchin Paracentrotus lividus, study of the transcription factors and SAR studies on nuclear receptors (e.g. COUP-TF; Chicken Ovalbumin Upstream Promoter–Transcription Factors)
- Irene Margiolaki, Lecturer in Structural Biology, Is a recently elected faculty member; expertise: in method development and application of Crystallography & Structural Biology. Extensive knowledge of powder and single crystal diffraction, structure determination, model building, refinement, and skills in Small Angle X-ray Scattering, optical/electron microscopy etc.
Recent publications
- Ahnfeldt T, Margiolaki I et al. Angew Chem Int Ed 48:5163-5166 (2009).
- Miller SR, Margiolaki I et al. J Am Chem Soc 130:15967-81 (2008).
- Margiolaki I, Wright JP, Wilmanns M, Fitch AN, Pinotsis N. J Am Chem Soc 129:11865-71 (2007).
- Sea Urchin Genome Sequencing Consortium (Flytzanis CN et al.) Science 314:941-952 (2006).
- Férey G, Mellot-Draznieks C, Serre C, Millange F, Dutour J, Surblé S, Margiolaki I Science 309:2040-2 (2005).
- Konstantopoulos AK, Flytzanis CN Mol Repro & Dev. 60:147-157 (2001).