“SEE-DRUG ” is a FP7 - RESEARH POTENTIAL project that aims to the upgrade the Structural Biology capacities of UPAT and to the Establishment of a Center of Excellence for Structure-Based Drug Target chracterization efforts in South-Eastern EU region.
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“SEE-STRUCT” is structure-oriented module of SEE-DRUG project and aims to the structural elucidation of proteins, enzymes and other interesting drug-targets. The tools offered for these efforts are a state-of-the-art high field NMR instrument of 700 MHz equipped with a highly sensitive probe and crystallization robot. Read the Full Story
“SEE-PROT” & “SEE-PHARM” are the protein production and the preclinical evaluation of molecules, modules of SEE-DRUG project. The tools offered for these efforts are protein production and characterization facilities an upgraded confocal microscope, an intravital microscope and myographs. Read the Full Story
- 1Research Facilities
- 2Scientific Expertise
- 3Networking & Dissemination
NMR
700MHz
High sensetivity probe
Studies in solution
Conformation/Dynamics
3D Structure determination, mobility, protein-protein interaction, protein-drug interactions
Confocal
In-cell imaging
Leica Microscope
Tandem Scanner
Additional laser
Sub-cellular ablation in live cells, protein-complexes, protein drug interactions in vivo
Robot
Crystal growth
Automation
Crystalization trials
Fast & efficient
Crystal growth optimization, screen of protein targes in paraller with NRM Spectroscopy
Microscopes
Myographs
intravital Microscope
In vivo
Ex vivo
Drug screening for anti-inflammatory compounds, evaluation of vasoactive compounds
Stuctural Biology
NMR & Xray
2H/13C/15N labeling
Selective labeling
Crystallization
Conformation dynamics, Modeling Structure determination, 3D solutions & crystal models, Bioinformatics
Molecular Biology
Biochemistry
Drug-targets
Biochemical pathways
Protein production
High-yield protein expression, labeling & isolation for structural studies, protein biochemistry
Imaging
In-cell studies
Functional imaging
Light Microscopy
FRET measurements
Studies of biomolecular functions through Advanced Light Microscopy, Sub-cellular ablations
Pharmacology
Inflammation
Vascular Biology
Cell-based assays
Signaling pathways
Monitoring cell processes (migration. proliferation, apoptosis), in vivo & ex vivo assays
Expertise Exchange
Twinnings
Knowledge transfer
Best practices
New applications
Exchange of researchers between UPAT and partnering organizations - EU Centers of excellence
Events
Workshops
Structural Biology
Biochemistry
Imaging
Workshops and scientific meetings will be organized at UPAT, Advanced training course in NMR
Dissemination
Conferences
Biomolecular NMR
Life Sciences
Analysis
Invited talks, Meeting participation & Poster presentations by SEE-DRUG members
Brokerage Events
Info-days
Meet the expers
Links with industry
Regional Authorities
Colloquia with invited speakers from academia or industry and private sector stakeholders
Experienced Investigators
Thursday, 22 December 2011 14:09
Last Updated on Friday, 27 November 2015 12:50
Experienced investigators who are currently working at the SEE-DRUG projects are:
| Investigators | Field of expertise |
Dr. Christos Chassapis | Field #1: Peptide/protein labeling strategies for NMR studies, data analysis & structure determination |
| Dr. Detlef Bentrop Dr. Stavros Bariamis | Field #2: Expert in Bio-NMR Spectroscopy Applications |
Dr Manousos E. Kambouris, Dr. Andrew Stewart | Field #3: Protein Crystallography & Biomolecular modeling/simulation |
Dr. George Lagoumintzis Dr. Sotiris Sideris | Field #4: Molecular Biology and Biochemistry |
Dr. Alexandra Patmanidi Dr. Christina Kyrousi | Field #5: Confocal and Functional Microscopy |
Dr. Panagiotis Panopoulos Dr. Zongmin Zhou, Dr. Glynos Constantinos | Field #6: In vitro assays used in vascular biology and inflammation |
Dr. Vasilis Kotsikoris Dr. Athanassios Spathis | Field #7: In vivo & ex vivo assays used in vascular biology and inflammation |
Dr. Marianthi Georgitsi | Field #8: Data acquisition/integration, database development & curation |
Upcoming Events
- 2nd EAB Meeting 13th May 2013
- 2nd SEE-DRUG Workshop - NMR Basics & Applications in Life Sciences, May 13-15, 2013
- 1st EAB Meeting, 23 April, 2012
- 1st SEE-DRUG Workshop - From Chemical to Systems Biology, 9-10 May, 2012
- A list with Scientific Events, April-May 2012
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FP7 Research & Innovation – Participants Portal – Calls for applications
International Meetings & Conferences
Journal Club
- 01 Jan 2012 Starting data of SEE-DRUG project
- 23 Feb 2012 Kick-off meeting
- 23 Apr2012 External Advisory Board meeting
- 29 Apr 2013 700MHz NMR installed