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“SEE-DRUG ” is a FP7 - RESEARH POTENTIAL project that aims to the upgrade the Structural Biology capacities of UPAT and to the Establishment of a Center of Excellence for Structure-Based Drug Target chracterization efforts in South-Eastern EU region.
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“SEE-STRUCT” is structure-oriented module of SEE-DRUG project and aims to the structural elucidation of proteins, enzymes and other interesting drug-targets. The tools offered for these efforts are a state-of-the-art high field NMR instrument of 700 MHz equipped with a highly sensitive probe and crystallization robot.
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“SEE-PROT” & “SEE-PHARM” are the protein production and the preclinical evaluation of molecules, modules of SEE-DRUG project. The tools offered for these efforts are protein production and characterization facilities an upgraded confocal microscope, an intravital microscope and myographs.
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High sensetivity probe
Studies in solution
3D Structure determination, mobility, protein-protein interaction, protein-drug interactions
In-cell imaging
Leica Microscope
Tandem Scanner
Additional laser
Sub-cellular ablation in live cells, protein-complexes, protein drug interactions in vivo
Crystal growth
Crystalization trials
Fast & efficient
Crystal growth optimization, screen of protein targes in paraller with NRM Spectroscopy
intravital Microscope
In vivo
Ex vivo
Drug screening for anti-inflammatory compounds, evaluation of vasoactive compounds

Stuctural Biology
NMR & Xray
2H/13C/15N labeling
Selective labeling
Conformation dynamics, Modeling Structure determination, 3D solutions & crystal models, Bioinformatics
Molecular Biology
Biochemical pathways
Protein production
High-yield protein expression, labeling & isolation for structural studies, protein biochemistry
In-cell studies
Functional imaging
Light Microscopy
FRET measurements
Studies of biomolecular functions through Advanced Light Microscopy, Sub-cellular ablations
Vascular Biology
Cell-based assays
Signaling pathways
Monitoring cell processes (migration. proliferation, apoptosis), in vivo & ex vivo assays

Expertise Exchange
Knowledge transfer
Best practices
New applications
Exchange of researchers between UPAT and partnering organizations - EU Centers of excellence
Structural Biology
Workshops and scientific meetings will be organized at UPAT, Advanced training course in NMR
Biomolecular NMR
Life Sciences
Invited talks, Meeting participation & Poster presentations by SEE-DRUG members
Brokerage Events
Meet the expers
Links with industry
Regional Authorities
Colloquia with invited speakers from academia or industry and private sector stakeholders

Brokerage Events – Info-days

The objective of the organization of activities such as Seminars, Info days and Links with Industrial, is to strengthen the links with industrial and R&D partners in the field of (bio)pharmaceutical technology not only in regional and national level, but also in EU and International level.

Seminars will be organized on a periodic basis and will focus on innovation building by UPAT and transfer of technology with industry/stakeholders. Researchers will give seminars while scientists from Greek Biotechnology & Pharmaceutical Industries/SMEs have already been contacted. These seminars will focus on innovation capacity building and for UPAT and the transfer of technology with industry/stakeholders.

Info days will be also organized with the aim to create links between UPAT staff and regional/national industry to promote growth and development and to inform research community and relative SMEs on SEE-DRUG project for the employment of new technologies.

Link to the list of SEE-DRUG meetings

Upcoming Events

Hot off the Press

porn /div> The NMR Structure of ARKADIA RING Domain (Proteins 2012, 50, 1484-89)

H2S and NO in angiogenesis & vasodilatation (PNAS 2012 in the press)

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International Meetings & Conferences

Journal Club

  • 01 Jan 2012 Starting data of SEE-DRUG project

  • 23 Feb 2012 Kick-off meeting

  • 23 Apr2012 External Advisory Board meeting

  • 29 Apr 2013 700MHz NMR installed