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“SEE-DRUG ” is a FP7 - RESEARH POTENTIAL project that aims to the upgrade the Structural Biology capacities of UPAT and to the Establishment of a Center of Excellence for Structure-Based Drug Target chracterization efforts in South-Eastern EU region.
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“SEE-STRUCT” is structure-oriented module of SEE-DRUG project and aims to the structural elucidation of proteins, enzymes and other interesting drug-targets. The tools offered for these efforts are a state-of-the-art high field NMR instrument of 700 MHz equipped with a highly sensitive probe and crystallization robot.
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“SEE-PROT” & “SEE-PHARM” are the protein production and the preclinical evaluation of molecules, modules of SEE-DRUG project. The tools offered for these efforts are protein production and characterization facilities an upgraded confocal microscope, an intravital microscope and myographs.
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NMR
700MHz
High sensetivity probe
Studies in solution
Conformation/Dynamics
3D Structure determination, mobility, protein-protein interaction, protein-drug interactions
Confocal
In-cell imaging
Leica Microscope
Tandem Scanner
Additional laser
Sub-cellular ablation in live cells, protein-complexes, protein drug interactions in vivo
Robot
Crystal growth
Automation
Crystalization trials
Fast & efficient
Crystal growth optimization, screen of protein targes in paraller with NRM Spectroscopy
Microscopes
Myographs
intravital Microscope
In vivo
Ex vivo
Drug screening for anti-inflammatory compounds, evaluation of vasoactive compounds

Stuctural Biology
NMR & Xray
2H/13C/15N labeling
Selective labeling
Crystallization
Conformation dynamics, Modeling Structure determination, 3D solutions & crystal models, Bioinformatics
Molecular Biology
Biochemistry
Drug-targets
Biochemical pathways
Protein production
High-yield protein expression, labeling & isolation for structural studies, protein biochemistry
Imaging
In-cell studies
Functional imaging
Light Microscopy
FRET measurements
Studies of biomolecular functions through Advanced Light Microscopy, Sub-cellular ablations
Pharmacology
Inflammation
Vascular Biology
Cell-based assays
Signaling pathways
Monitoring cell processes (migration. proliferation, apoptosis), in vivo & ex vivo assays

Expertise Exchange
Twinnings
Knowledge transfer
Best practices
New applications
Exchange of researchers between UPAT and partnering organizations - EU Centers of excellence
Events
Workshops
Structural Biology
Biochemistry
Imaging
Workshops and scientific meetings will be organized at UPAT, Advanced training course in NMR
Dissemination
Conferences
Biomolecular NMR
Life Sciences
Analysis
Invited talks, Meeting participation & Poster presentations by SEE-DRUG members
Brokerage Events
Info-days
Meet the expers
Links with industry
Regional Authorities
Colloquia with invited speakers from academia or industry and private sector stakeholders

Kick-of Meeting – SEE-DRUG project (FP7-REGPOT-2011-1)

THURSDAY 23rd FEBRUARY 2012

Conference & Cultural Center
University of Patras
Room II-9 (1st Floor)

Chairpersons

G.A. Spyroulias (Dept of Pharmacy) & N. Moschonas (Dept of Medicine)

09:30 – 9:45Welcome Addresses - Introduction
University of Patras Authorities

09:50 – 10:10

The SEE-DRUG project – Biomolecular NMR @UPAT
Georgios A. Spyroulias
University of Patras, Department of Pharmacy, Hellas

10:10 – 10:40

Enhancement of TGFbeta signaling responses by Arkadia is required for tumor suppression in CRC
Vasso Episkopou
Imperial College, London, UK

10:40 – 11:00

Pharmacological modulation of gasotransmitter levels and activity
Andreas Papapetropoulos

University of Patras, Department of Pharmacy, Hellas

11:00 – 11:20

Pharmacological control of arterial smooth muscle and endothelial cell phenotype
Stavros Topouzis

University of Patras, Department of Pharmacy, Hellas

11:20 – 11:40

Biochemical and bioinformatics tools for understanding autoimmune and genetic disorders
Kostas Poulas / George Patrinos

University of Patras, Department of Pharmacy, Hellas

11:40 – 12:00Coffee Break
Chairpersons

 I. Margiolaki (Dept of Biology) K. Poulas (Dept of Pharmacy)

12:30 – 12:50

Autotaxin, there and back again: inhibitors, structures, interactions, function
Anastassis Perakis
National Cancer Institute (NKI), Amsterdam, The Netherlands

12:30 – 12:50

Reconstructing the known human protein-protein interaction network from major literature-curated databases
Nicholas Moschonas
University of Patras, Department of Medicine, Hellas

12:50 – 13:10

Control of DNA replication in time and space
Zoi Lygerou
University of Patras, Department of Medicine, Hellas

13:10 – 13:30

Mechanisms that control self-renewal and differentiation decisions of stem cells in physiology and disease
Stavros Taraviras
University of Patras, Department of Medicine, Hellas

13:30 – 15:00Light lunch & Coffee
Chairpersons

 Z. Lygerou (Dept of Medicine) & S. Topouzis (Dept of Pharmacy)

15:00 – 15:20

Coup-TF Variants: Function and Evolution
Costas Flytzanis

University of Patras, Department of Biology, Hellas

15:20 – 15:40

Macromolecular Powder Diffraction: Current Status & Future Prospect
Irene Margiolaki

University of Patras, Department of Biology, Hellas

15:40 – 16:00

Thioredoxin and glutaredoxin systems: biochemistry and structure
Alexios Vlamis

University of Patras, Department of Chemistry, Hellas

16:00 – 16:20

From peptides to non-peptide mimetics: A new generation of drugs
Theodoros Tselios
University of Patras, Department of Chemistry, Hellas

16:20 – 16:30Closing Remarks


You can download the program of the meeting in PDF format here

Upcoming Events

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  • 01 Jan 2012 Starting data of SEE-DRUG project

  • 23 Feb 2012 Kick-off meeting

  • 23 Apr2012 External Advisory Board meeting

  • 29 Apr 2013 700MHz NMR installed