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“SEE-DRUG ” is a FP7 - RESEARH POTENTIAL project that aims to the upgrade the Structural Biology capacities of UPAT and to the Establishment of a Center of Excellence for Structure-Based Drug Target chracterization efforts in South-Eastern EU region.
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“SEE-STRUCT” is structure-oriented module of SEE-DRUG project and aims to the structural elucidation of proteins, enzymes and other interesting drug-targets. The tools offered for these efforts are a state-of-the-art high field NMR instrument of 700 MHz equipped with a highly sensitive probe and crystallization robot.
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“SEE-PROT” & “SEE-PHARM” are the protein production and the preclinical evaluation of molecules, modules of SEE-DRUG project. The tools offered for these efforts are protein production and characterization facilities an upgraded confocal microscope, an intravital microscope and myographs.
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High sensetivity probe
Studies in solution
3D Structure determination, mobility, protein-protein interaction, protein-drug interactions
In-cell imaging
Leica Microscope
Tandem Scanner
Additional laser
Sub-cellular ablation in live cells, protein-complexes, protein drug interactions in vivo
Crystal growth
Crystalization trials
Fast & efficient
Crystal growth optimization, screen of protein targes in paraller with NRM Spectroscopy
intravital Microscope
In vivo
Ex vivo
Drug screening for anti-inflammatory compounds, evaluation of vasoactive compounds

Stuctural Biology
NMR & Xray
2H/13C/15N labeling
Selective labeling
Conformation dynamics, Modeling Structure determination, 3D solutions & crystal models, Bioinformatics
Molecular Biology
Biochemical pathways
Protein production
High-yield protein expression, labeling & isolation for structural studies, protein biochemistry
In-cell studies
Functional imaging
Light Microscopy
FRET measurements
Studies of biomolecular functions through Advanced Light Microscopy, Sub-cellular ablations
Vascular Biology
Cell-based assays
Signaling pathways
Monitoring cell processes (migration. proliferation, apoptosis), in vivo & ex vivo assays

Expertise Exchange
Knowledge transfer
Best practices
New applications
Exchange of researchers between UPAT and partnering organizations - EU Centers of excellence
Structural Biology
Workshops and scientific meetings will be organized at UPAT, Advanced training course in NMR
Biomolecular NMR
Life Sciences
Invited talks, Meeting participation & Poster presentations by SEE-DRUG members
Brokerage Events
Meet the expers
Links with industry
Regional Authorities
Colloquia with invited speakers from academia or industry and private sector stakeholders

Kick-of Meeting – SEE-DRUG project (FP7-REGPOT-2011-1)


Conference & Cultural Center
University of Patras
Room II-9 (1st Floor)


G.A. Spyroulias (Dept of Pharmacy) & N. Moschonas (Dept of Medicine)

09:30 – 9:45Welcome Addresses - Introduction
University of Patras Authorities

09:50 – 10:10

The SEE-DRUG project – Biomolecular NMR @UPAT
Georgios A. Spyroulias
University of Patras, Department of Pharmacy, Hellas

10:10 – 10:40

Enhancement of TGFbeta signaling responses by Arkadia is required for tumor suppression in CRC
Vasso Episkopou
Imperial College, London, UK

10:40 – 11:00

Pharmacological modulation of gasotransmitter levels and activity
Andreas Papapetropoulos

University of Patras, Department of Pharmacy, Hellas

11:00 – 11:20

Pharmacological control of arterial smooth muscle and endothelial cell phenotype
Stavros Topouzis

University of Patras, Department of Pharmacy, Hellas

11:20 – 11:40

Biochemical and bioinformatics tools for understanding autoimmune and genetic disorders
Kostas Poulas / George Patrinos

University of Patras, Department of Pharmacy, Hellas

11:40 – 12:00Coffee Break

 I. Margiolaki (Dept of Biology) K. Poulas (Dept of Pharmacy)

12:30 – 12:50

Autotaxin, there and back again: inhibitors, structures, interactions, function
Anastassis Perakis
National Cancer Institute (NKI), Amsterdam, The Netherlands

12:30 – 12:50

Reconstructing the known human protein-protein interaction network from major literature-curated databases
Nicholas Moschonas
University of Patras, Department of Medicine, Hellas

12:50 – 13:10

Control of DNA replication in time and space
Zoi Lygerou
University of Patras, Department of Medicine, Hellas

13:10 – 13:30

Mechanisms that control self-renewal and differentiation decisions of stem cells in physiology and disease
Stavros Taraviras
University of Patras, Department of Medicine, Hellas

13:30 – 15:00Light lunch & Coffee

 Z. Lygerou (Dept of Medicine) & S. Topouzis (Dept of Pharmacy)

15:00 – 15:20

Coup-TF Variants: Function and Evolution
Costas Flytzanis

University of Patras, Department of Biology, Hellas

15:20 – 15:40

Macromolecular Powder Diffraction: Current Status & Future Prospect
Irene Margiolaki

University of Patras, Department of Biology, Hellas

15:40 – 16:00

Thioredoxin and glutaredoxin systems: biochemistry and structure
Alexios Vlamis

University of Patras, Department of Chemistry, Hellas

16:00 – 16:20

From peptides to non-peptide mimetics: A new generation of drugs
Theodoros Tselios
University of Patras, Department of Chemistry, Hellas

16:20 – 16:30Closing Remarks

You can download the program of the meeting in PDF format here

Upcoming Events

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  • 01 Jan 2012 Starting data of SEE-DRUG project

  • 23 Feb 2012 Kick-off meeting

  • 23 Apr2012 External Advisory Board meeting

  • 29 Apr 2013 700MHz NMR installed