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“SEE-DRUG ” is a FP7 - RESEARH POTENTIAL project that aims to the upgrade the Structural Biology capacities of UPAT and to the Establishment of a Center of Excellence for Structure-Based Drug Target chracterization efforts in South-Eastern EU region.
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“SEE-STRUCT” is structure-oriented module of SEE-DRUG project and aims to the structural elucidation of proteins, enzymes and other interesting drug-targets. The tools offered for these efforts are a state-of-the-art high field NMR instrument of 700 MHz equipped with a highly sensitive probe and crystallization robot.
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“SEE-PROT” & “SEE-PHARM” are the protein production and the preclinical evaluation of molecules, modules of SEE-DRUG project. The tools offered for these efforts are protein production and characterization facilities an upgraded confocal microscope, an intravital microscope and myographs.
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NMR
700MHz
High sensetivity probe
Studies in solution
Conformation/Dynamics
3D Structure determination, mobility, protein-protein interaction, protein-drug interactions
Confocal
In-cell imaging
Leica Microscope
Tandem Scanner
Additional laser
Sub-cellular ablation in live cells, protein-complexes, protein drug interactions in vivo
Robot
Crystal growth
Automation
Crystalization trials
Fast & efficient
Crystal growth optimization, screen of protein targes in paraller with NRM Spectroscopy
Microscopes
Myographs
intravital Microscope
In vivo
Ex vivo
Drug screening for anti-inflammatory compounds, evaluation of vasoactive compounds

Stuctural Biology
NMR & Xray
2H/13C/15N labeling
Selective labeling
Crystallization
Conformation dynamics, Modeling Structure determination, 3D solutions & crystal models, Bioinformatics
Molecular Biology
Biochemistry
Drug-targets
Biochemical pathways
Protein production
High-yield protein expression, labeling & isolation for structural studies, protein biochemistry
Imaging
In-cell studies
Functional imaging
Light Microscopy
FRET measurements
Studies of biomolecular functions through Advanced Light Microscopy, Sub-cellular ablations
Pharmacology
Inflammation
Vascular Biology
Cell-based assays
Signaling pathways
Monitoring cell processes (migration. proliferation, apoptosis), in vivo & ex vivo assays

Expertise Exchange
Twinnings
Knowledge transfer
Best practices
New applications
Exchange of researchers between UPAT and partnering organizations - EU Centers of excellence
Events
Workshops
Structural Biology
Biochemistry
Imaging
Workshops and scientific meetings will be organized at UPAT, Advanced training course in NMR
Dissemination
Conferences
Biomolecular NMR
Life Sciences
Analysis
Invited talks, Meeting participation & Poster presentations by SEE-DRUG members
Brokerage Events
Info-days
Meet the expers
Links with industry
Regional Authorities
Colloquia with invited speakers from academia or industry and private sector stakeholders

Events – Workshops

The objectives of these actions are to organize networking and co-operations activities, bringing together experts and younger researchers and to organize high-impact international conference. The foreseen activities include the organization of four workshops to cover all modern topics of synthetic/chemical biology, biophysical characterization of biomolecules, preclinical studies of bioactive compounds, in-cell imaging with confocal and functional microscopy and structural biology, under the general title “From Chemical to Structural Biology”. The organization of these workshops will facilitate the transfer of knowledge through networking activities between the applicant and other EU well-established research entities from developed countries.

A high-impact international conference on the impact of NMR methodology in Life Sciences, and in particular in chemical, structural and systems biology, in drug discovery and metabonomics, will be held during the third year of the project.

 Young or experienced researchers, PhD candidates, graduate or undergraduate students are welcome to join these events, to meet the experts and to discuss and exchange ideas.

 Specifically:

(i) Workshop 1: Peptide Synthesis and Protein production/labeling. 9-10 May 2012.

(ii) Workshop 2: NMR Basics and Applications in Life Sciences + Skill Cours. 9-10 May 2013.

(iii) Workshop 3: Emerging Analytical Techniques in Protein Characterization. Tentative date 09/2013.

(iv) Workshop 4: Live cell imaging, Drug Screening & Preclinical assessment. Tentative date 05/2014.

Link to the list of SEE-DRUG meetings

Conference in “NMR Applications in Structural genomics/Proteomics”. Tentative date 06/2014 or 09/2014.

Link to the list of SEE-DRUG meetings

 

Upcoming Events

Hot off the Press

porn /div> The NMR Structure of ARKADIA RING Domain (Proteins 2012, 50, 1484-89)

H2S and NO in angiogenesis & vasodilatation (PNAS 2012 in the press)

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International Meetings & Conferences

Journal Club

  • 01 Jan 2012 Starting data of SEE-DRUG project

  • 23 Feb 2012 Kick-off meeting

  • 23 Apr2012 External Advisory Board meeting

  • 29 Apr 2013 700MHz NMR installed