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“SEE-DRUG ” is a FP7 - RESEARH POTENTIAL project that aims to the upgrade the Structural Biology capacities of UPAT and to the Establishment of a Center of Excellence for Structure-Based Drug Target chracterization efforts in South-Eastern EU region.
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“SEE-STRUCT” is structure-oriented module of SEE-DRUG project and aims to the structural elucidation of proteins, enzymes and other interesting drug-targets. The tools offered for these efforts are a state-of-the-art high field NMR instrument of 700 MHz equipped with a highly sensitive probe and crystallization robot.
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“SEE-PROT” & “SEE-PHARM” are the protein production and the preclinical evaluation of molecules, modules of SEE-DRUG project. The tools offered for these efforts are protein production and characterization facilities an upgraded confocal microscope, an intravital microscope and myographs.
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NMR
700MHz
High sensetivity probe
Studies in solution
Conformation/Dynamics
3D Structure determination, mobility, protein-protein interaction, protein-drug interactions
Confocal
In-cell imaging
Leica Microscope
Tandem Scanner
Additional laser
Sub-cellular ablation in live cells, protein-complexes, protein drug interactions in vivo
Robot
Crystal growth
Automation
Crystalization trials
Fast & efficient
Crystal growth optimization, screen of protein targes in paraller with NRM Spectroscopy
Microscopes
Myographs
intravital Microscope
In vivo
Ex vivo
Drug screening for anti-inflammatory compounds, evaluation of vasoactive compounds

Stuctural Biology
NMR & Xray
2H/13C/15N labeling
Selective labeling
Crystallization
Conformation dynamics, Modeling Structure determination, 3D solutions & crystal models, Bioinformatics
Molecular Biology
Biochemistry
Drug-targets
Biochemical pathways
Protein production
High-yield protein expression, labeling & isolation for structural studies, protein biochemistry
Imaging
In-cell studies
Functional imaging
Light Microscopy
FRET measurements
Studies of biomolecular functions through Advanced Light Microscopy, Sub-cellular ablations
Pharmacology
Inflammation
Vascular Biology
Cell-based assays
Signaling pathways
Monitoring cell processes (migration. proliferation, apoptosis), in vivo & ex vivo assays

Expertise Exchange
Twinnings
Knowledge transfer
Best practices
New applications
Exchange of researchers between UPAT and partnering organizations - EU Centers of excellence
Events
Workshops
Structural Biology
Biochemistry
Imaging
Workshops and scientific meetings will be organized at UPAT, Advanced training course in NMR
Dissemination
Conferences
Biomolecular NMR
Life Sciences
Analysis
Invited talks, Meeting participation & Poster presentations by SEE-DRUG members
Brokerage Events
Info-days
Meet the expers
Links with industry
Regional Authorities
Colloquia with invited speakers from academia or industry and private sector stakeholders

Impact

SEE-DRUG’s uniqueness is based on the combination of the two features: first, it implements a strong collaborative institutional network of high-quality expertise, and second, improves and extends the national research activities beyond the state-of-the-art in the field of Structural and Chemical Biology. The latter is accomplished by tightly linking Structural Biology to multi-facetted biological characterization of the chosen drug target and thus it produces highly novel mechanistic and functional insights regarding both known as well as novel therapeutic targets.

The SEE-DRUG project addresses the rapid developments in Chemical and Molecular Systems Biology throughout Europe and ambitions to couple these fields for added synergy. In doing so, the SEE-DRUG proposal will certainly strengthen the Greek and South Eastern EU research capacity by providing a unique to the region infrastructure to tackle cutting-edge research problems that are acknowledged top priorities S&T fields in the EU. As a consequence, the project will have the following primary impacts:

- SEE-DRUG will enable UPAT to perform both atomic-level characterizations of protein targets as well as functional screening/optimization of molecules that interact with them (and modulating their activity), thus combining and coupling powerful NMR-based Structural Biology to an array of Pharmacological assays.

- The benefit of obtaining the core instrument, 700 MHz NMR, will be multiple: by exploiting its capability to process small sample amounts, it will enable and accelerate high quality research activities within the SEE-DRUG group and will enable new collaborations with regional and transnational partners.

- SEE-DRUG will significantly improve UPAT’s visibility by strengthening its research and technological capacity. It will also boost regional S&T scientific potential, enhance the quality level and number of skilled, expert scientists in the area and will create a unique pole in the region.

- SEE-DRUG will promote national and trans-national access to UPAT infrastructure and will stimulate co-operative and networking activities of UPAT with other laboratories, research centres and academia, in Greece, Eastern and SouthEastern EU countries.

SEE-DRUG is also expected to contribute significantly in the social-economic growth of the Achaia region and the wider area of Western Greece, through the building of scientific network with EU Centers of Excellence, with countries in the Balkan peninsula and with national/regional industries

Upcoming Events

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  • 01 Jan 2012 Starting data of SEE-DRUG project

  • 23 Feb 2012 Kick-off meeting

  • 23 Apr2012 External Advisory Board meeting

  • 29 Apr 2013 700MHz NMR installed