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“SEE-DRUG ” is a FP7 - RESEARH POTENTIAL project that aims to the upgrade the Structural Biology capacities of UPAT and to the Establishment of a Center of Excellence for Structure-Based Drug Target chracterization efforts in South-Eastern EU region.
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“SEE-STRUCT” is structure-oriented module of SEE-DRUG project and aims to the structural elucidation of proteins, enzymes and other interesting drug-targets. The tools offered for these efforts are a state-of-the-art high field NMR instrument of 700 MHz equipped with a highly sensitive probe and crystallization robot.
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“SEE-PROT” & “SEE-PHARM” are the protein production and the preclinical evaluation of molecules, modules of SEE-DRUG project. The tools offered for these efforts are protein production and characterization facilities an upgraded confocal microscope, an intravital microscope and myographs.
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NMR
700MHz
High sensetivity probe
Studies in solution
Conformation/Dynamics
3D Structure determination, mobility, protein-protein interaction, protein-drug interactions
Confocal
In-cell imaging
Leica Microscope
Tandem Scanner
Additional laser
Sub-cellular ablation in live cells, protein-complexes, protein drug interactions in vivo
Robot
Crystal growth
Automation
Crystalization trials
Fast & efficient
Crystal growth optimization, screen of protein targes in paraller with NRM Spectroscopy
Microscopes
Myographs
intravital Microscope
In vivo
Ex vivo
Drug screening for anti-inflammatory compounds, evaluation of vasoactive compounds

Stuctural Biology
NMR & Xray
2H/13C/15N labeling
Selective labeling
Crystallization
Conformation dynamics, Modeling Structure determination, 3D solutions & crystal models, Bioinformatics
Molecular Biology
Biochemistry
Drug-targets
Biochemical pathways
Protein production
High-yield protein expression, labeling & isolation for structural studies, protein biochemistry
Imaging
In-cell studies
Functional imaging
Light Microscopy
FRET measurements
Studies of biomolecular functions through Advanced Light Microscopy, Sub-cellular ablations
Pharmacology
Inflammation
Vascular Biology
Cell-based assays
Signaling pathways
Monitoring cell processes (migration. proliferation, apoptosis), in vivo & ex vivo assays

Expertise Exchange
Twinnings
Knowledge transfer
Best practices
New applications
Exchange of researchers between UPAT and partnering organizations - EU Centers of excellence
Events
Workshops
Structural Biology
Biochemistry
Imaging
Workshops and scientific meetings will be organized at UPAT, Advanced training course in NMR
Dissemination
Conferences
Biomolecular NMR
Life Sciences
Analysis
Invited talks, Meeting participation & Poster presentations by SEE-DRUG members
Brokerage Events
Info-days
Meet the expers
Links with industry
Regional Authorities
Colloquia with invited speakers from academia or industry and private sector stakeholders

Expertise Exchange – Twinnings

CERMFlorence, Italy

GOETHE University

Frankfurt, Germany

Imperial CollegeLondon, UK


National Cancer Institute (NKI)Amsterdam, The Netherlands


MPIDortmund, Germany


ESRFGrenoble, France


BMRZFrankfurt, Germany


CNCRAmsterdam, The Netherlands


Expertise Exchange and Twinning Activities aiming to provide opportunities to the researchers of the UPAT SEE-DRUG, to meet experts in the fields of Chemical, Structural Biology and Pharmacology and to visit EU Center of Excellence (Partnering Organizations, PO). Two sided visits (incoming & outgoing visits) of each participant or members of the groups are planned for expertise exchange, and transfer of knowledge. Emphasis is given to the active involvement of s many as possible participants of SEE-DRUG consortium, involving thus a significant number of experienced researchers. This action will facilitate the transfer of knowledge and best practices to UPAT. Experienced researchers from EU Centers of Excellence that will collaborate with the SEE-DRUG groups, as Partnering Organizations, will participate in the External Advisory Board of the project and will participate in networking/twinning activities (see above Chart).

Incoming Visits

Experienced researchers from the 8 Partnering Organizations, will be involved in twinning activities for scientific research purposes and for transfer of knowledge in the areas covered by SEE-DRUG.

Outgoing Visits

SEE-DRUG participants and/or members of their groups will spent some weeks in one of the EU Experts Lab/Institutes/Centers (see above Chart), over the 36 months duration of the SEE-DRUG.

Upcoming Events

Hot off the Press

porn /div> The NMR Structure of ARKADIA RING Domain (Proteins 2012, 50, 1484-89)

H2S and NO in angiogenesis & vasodilatation (PNAS 2012 in the press)

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  • 01 Jan 2012 Starting data of SEE-DRUG project

  • 23 Feb 2012 Kick-off meeting

  • 23 Apr2012 External Advisory Board meeting

  • 29 Apr 2013 700MHz NMR installed