image image image

“SEE-DRUG ” is a FP7 - RESEARH POTENTIAL project that aims to the upgrade the Structural Biology capacities of UPAT and to the Establishment of a Center of Excellence for Structure-Based Drug Target chracterization efforts in South-Eastern EU region.
Read the Full Story

“SEE-STRUCT” is structure-oriented module of SEE-DRUG project and aims to the structural elucidation of proteins, enzymes and other interesting drug-targets. The tools offered for these efforts are a state-of-the-art high field NMR instrument of 700 MHz equipped with a highly sensitive probe and crystallization robot.
Read the Full Story

“SEE-PROT” & “SEE-PHARM” are the protein production and the preclinical evaluation of molecules, modules of SEE-DRUG project. The tools offered for these efforts are protein production and characterization facilities an upgraded confocal microscope, an intravital microscope and myographs.
Read the Full Story

NMR
700MHz
High sensetivity probe
Studies in solution
Conformation/Dynamics
3D Structure determination, mobility, protein-protein interaction, protein-drug interactions
Confocal
In-cell imaging
Leica Microscope
Tandem Scanner
Additional laser
Sub-cellular ablation in live cells, protein-complexes, protein drug interactions in vivo
Robot
Crystal growth
Automation
Crystalization trials
Fast & efficient
Crystal growth optimization, screen of protein targes in paraller with NRM Spectroscopy
Microscopes
Myographs
intravital Microscope
In vivo
Ex vivo
Drug screening for anti-inflammatory compounds, evaluation of vasoactive compounds

Stuctural Biology
NMR & Xray
2H/13C/15N labeling
Selective labeling
Crystallization
Conformation dynamics, Modeling Structure determination, 3D solutions & crystal models, Bioinformatics
Molecular Biology
Biochemistry
Drug-targets
Biochemical pathways
Protein production
High-yield protein expression, labeling & isolation for structural studies, protein biochemistry
Imaging
In-cell studies
Functional imaging
Light Microscopy
FRET measurements
Studies of biomolecular functions through Advanced Light Microscopy, Sub-cellular ablations
Pharmacology
Inflammation
Vascular Biology
Cell-based assays
Signaling pathways
Monitoring cell processes (migration. proliferation, apoptosis), in vivo & ex vivo assays

Expertise Exchange
Twinnings
Knowledge transfer
Best practices
New applications
Exchange of researchers between UPAT and partnering organizations - EU Centers of excellence
Events
Workshops
Structural Biology
Biochemistry
Imaging
Workshops and scientific meetings will be organized at UPAT, Advanced training course in NMR
Dissemination
Conferences
Biomolecular NMR
Life Sciences
Analysis
Invited talks, Meeting participation & Poster presentations by SEE-DRUG members
Brokerage Events
Info-days
Meet the expers
Links with industry
Regional Authorities
Colloquia with invited speakers from academia or industry and private sector stakeholders

Structural Biology NMR & Xray Applications

Expertise in NMR Structural Biology - (a) protein uniform, selective and/or specific labelling in 13C, 15N, 2H for advanced studies of high molecular weight biomolecules or complexes with NMR (SEE-STRUCT module), (b) NMR application specialists, for conformational dynamics studies of proteins and NMR-driven drug design efforts, set up of projection spectroscopy applications and data analysis (c) analysis of NMR data and protein structure determination, (d) NMR studies of paramagnetic metalloproteins, (e) screening with NMR spectroscopy the properties of the produced recombinant proteins (folding, solubility, stability, aggregation state, etc.), in order to increase the success rate in crystallization trials, (f) training of existed UPAT research staff in non-standard protocols for protein expression, isolation and/or labelling not currently available in UPAT and in Greek academia.

Expertise in Protein Crystallography and modelling(a) crystal structure determination, and experience in drug design (SEE-STRUCT module), (b) experience in crystallization trials, crystallization screening conditions, and set up of the crystallization robot (sitting-drop vapour-diffusion crystallization experiments), (c) analysis of the NMR data concerning the experimental conditions and the suitability of proteins for crystallization trials, (d) experience in computational biology, biomolecular modeling (homology modeling & docking simulations), data mining and analysis.

Expertise in data acquisition/integration, database development and curation expert – set up of an integrated platform for the collection of the data from the collaborating groups; three individual databases for each one of the SEE-PROT, SEE-STRUCT, and SEE-PHARM modules facilitating the biological data modelling, handling and integration for relational (SQL-based) databases and related applications, requirement gathering, database design/data modelling and statistical analysis. Application of data handling standards for the data generated and also implement or guide the new data curation pipelines and tools.

Upcoming Events

Hot off the Press

porn /div> The NMR Structure of ARKADIA RING Domain (Proteins 2012, 50, 1484-89)

H2S and NO in angiogenesis & vasodilatation (PNAS 2012 in the press)

Site Statistics

mod_vvisit_countermod_vvisit_countermod_vvisit_countermod_vvisit_countermod_vvisit_countermod_vvisit_counter
mod_vvisit_counterToday20
mod_vvisit_counterYesterday92
mod_vvisit_counterThis week359
mod_vvisit_counterLast week319
mod_vvisit_counterThis month1127
mod_vvisit_counterLast month1711
mod_vvisit_counterAll days182687

We have: 18 guests online
Your IP: 23.20.13.165
 , 
Today: Sep 23, 2017
University of Patras General Info, Services, Research Committee, etc.

FP7 Research & Innovation – Participants Portal – Calls for applications

International Meetings & Conferences

Journal Club

  • 01 Jan 2012 Starting data of SEE-DRUG project

  • 23 Feb 2012 Kick-off meeting

  • 23 Apr2012 External Advisory Board meeting

  • 29 Apr 2013 700MHz NMR installed