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“SEE-DRUG ” is a FP7 - RESEARH POTENTIAL project that aims to the upgrade the Structural Biology capacities of UPAT and to the Establishment of a Center of Excellence for Structure-Based Drug Target chracterization efforts in South-Eastern EU region.
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“SEE-STRUCT” is structure-oriented module of SEE-DRUG project and aims to the structural elucidation of proteins, enzymes and other interesting drug-targets. The tools offered for these efforts are a state-of-the-art high field NMR instrument of 700 MHz equipped with a highly sensitive probe and crystallization robot.
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“SEE-PROT” & “SEE-PHARM” are the protein production and the preclinical evaluation of molecules, modules of SEE-DRUG project. The tools offered for these efforts are protein production and characterization facilities an upgraded confocal microscope, an intravital microscope and myographs.
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High sensetivity probe
Studies in solution
3D Structure determination, mobility, protein-protein interaction, protein-drug interactions
In-cell imaging
Leica Microscope
Tandem Scanner
Additional laser
Sub-cellular ablation in live cells, protein-complexes, protein drug interactions in vivo
Crystal growth
Crystalization trials
Fast & efficient
Crystal growth optimization, screen of protein targes in paraller with NRM Spectroscopy
intravital Microscope
In vivo
Ex vivo
Drug screening for anti-inflammatory compounds, evaluation of vasoactive compounds

Stuctural Biology
NMR & Xray
2H/13C/15N labeling
Selective labeling
Conformation dynamics, Modeling Structure determination, 3D solutions & crystal models, Bioinformatics
Molecular Biology
Biochemical pathways
Protein production
High-yield protein expression, labeling & isolation for structural studies, protein biochemistry
In-cell studies
Functional imaging
Light Microscopy
FRET measurements
Studies of biomolecular functions through Advanced Light Microscopy, Sub-cellular ablations
Vascular Biology
Cell-based assays
Signaling pathways
Monitoring cell processes (migration. proliferation, apoptosis), in vivo & ex vivo assays

Expertise Exchange
Knowledge transfer
Best practices
New applications
Exchange of researchers between UPAT and partnering organizations - EU Centers of excellence
Structural Biology
Workshops and scientific meetings will be organized at UPAT, Advanced training course in NMR
Biomolecular NMR
Life Sciences
Invited talks, Meeting participation & Poster presentations by SEE-DRUG members
Brokerage Events
Meet the expers
Links with industry
Regional Authorities
Colloquia with invited speakers from academia or industry and private sector stakeholders

Structural Biology NMR & Xray Applications

Expertise in NMR Structural Biology - (a) protein uniform, selective and/or specific labelling in 13C, 15N, 2H for advanced studies of high molecular weight biomolecules or complexes with NMR (SEE-STRUCT module), (b) NMR application specialists, for conformational dynamics studies of proteins and NMR-driven drug design efforts, set up of projection spectroscopy applications and data analysis (c) analysis of NMR data and protein structure determination, (d) NMR studies of paramagnetic metalloproteins, (e) screening with NMR spectroscopy the properties of the produced recombinant proteins (folding, solubility, stability, aggregation state, etc.), in order to increase the success rate in crystallization trials, (f) training of existed UPAT research staff in non-standard protocols for protein expression, isolation and/or labelling not currently available in UPAT and in Greek academia.

Expertise in Protein Crystallography and modelling(a) crystal structure determination, and experience in drug design (SEE-STRUCT module), (b) experience in crystallization trials, crystallization screening conditions, and set up of the crystallization robot (sitting-drop vapour-diffusion crystallization experiments), (c) analysis of the NMR data concerning the experimental conditions and the suitability of proteins for crystallization trials, (d) experience in computational biology, biomolecular modeling (homology modeling & docking simulations), data mining and analysis.

Expertise in data acquisition/integration, database development and curation expert – set up of an integrated platform for the collection of the data from the collaborating groups; three individual databases for each one of the SEE-PROT, SEE-STRUCT, and SEE-PHARM modules facilitating the biological data modelling, handling and integration for relational (SQL-based) databases and related applications, requirement gathering, database design/data modelling and statistical analysis. Application of data handling standards for the data generated and also implement or guide the new data curation pipelines and tools.

Upcoming Events

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  • 01 Jan 2012 Starting data of SEE-DRUG project

  • 23 Feb 2012 Kick-off meeting

  • 23 Apr2012 External Advisory Board meeting

  • 29 Apr 2013 700MHz NMR installed