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“SEE-DRUG ” is a FP7 - RESEARH POTENTIAL project that aims to the upgrade the Structural Biology capacities of UPAT and to the Establishment of a Center of Excellence for Structure-Based Drug Target chracterization efforts in South-Eastern EU region.
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“SEE-STRUCT” is structure-oriented module of SEE-DRUG project and aims to the structural elucidation of proteins, enzymes and other interesting drug-targets. The tools offered for these efforts are a state-of-the-art high field NMR instrument of 700 MHz equipped with a highly sensitive probe and crystallization robot.
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“SEE-PROT” & “SEE-PHARM” are the protein production and the preclinical evaluation of molecules, modules of SEE-DRUG project. The tools offered for these efforts are protein production and characterization facilities an upgraded confocal microscope, an intravital microscope and myographs.
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NMR
700MHz
High sensetivity probe
Studies in solution
Conformation/Dynamics
3D Structure determination, mobility, protein-protein interaction, protein-drug interactions
Confocal
In-cell imaging
Leica Microscope
Tandem Scanner
Additional laser
Sub-cellular ablation in live cells, protein-complexes, protein drug interactions in vivo
Robot
Crystal growth
Automation
Crystalization trials
Fast & efficient
Crystal growth optimization, screen of protein targes in paraller with NRM Spectroscopy
Microscopes
Myographs
intravital Microscope
In vivo
Ex vivo
Drug screening for anti-inflammatory compounds, evaluation of vasoactive compounds

Stuctural Biology
NMR & Xray
2H/13C/15N labeling
Selective labeling
Crystallization
Conformation dynamics, Modeling Structure determination, 3D solutions & crystal models, Bioinformatics
Molecular Biology
Biochemistry
Drug-targets
Biochemical pathways
Protein production
High-yield protein expression, labeling & isolation for structural studies, protein biochemistry
Imaging
In-cell studies
Functional imaging
Light Microscopy
FRET measurements
Studies of biomolecular functions through Advanced Light Microscopy, Sub-cellular ablations
Pharmacology
Inflammation
Vascular Biology
Cell-based assays
Signaling pathways
Monitoring cell processes (migration. proliferation, apoptosis), in vivo & ex vivo assays

Expertise Exchange
Twinnings
Knowledge transfer
Best practices
New applications
Exchange of researchers between UPAT and partnering organizations - EU Centers of excellence
Events
Workshops
Structural Biology
Biochemistry
Imaging
Workshops and scientific meetings will be organized at UPAT, Advanced training course in NMR
Dissemination
Conferences
Biomolecular NMR
Life Sciences
Analysis
Invited talks, Meeting participation & Poster presentations by SEE-DRUG members
Brokerage Events
Info-days
Meet the expers
Links with industry
Regional Authorities
Colloquia with invited speakers from academia or industry and private sector stakeholders

Job opportunities

JOB OPPORTUNITIES for EXPERIENCED RESEARCHERS & TECHNICAL PERSONNEL

at the University of Patras (UPAT), GREECE.

Participants: Departments of Pharmacy, Medicine, Chemistry and Biology

DESCRIPTION

Candidates should have a PhD in Biological and Chemical Sciences (e.g. Biochemistry, Structural Biology, Pharmacology), with solid background and at least 4-years of relevant post-Ph.D. expertise in the fields covered by the “SEE-DRUG”. The Aim of SEE-DRUG is the discovery and characterization of bioactive drug candidates, using a rational, Structural Biology-based drug-design approach. It combines on-site multidisciplinary expertise in the fields of Chemistry, Biology, Pharmacology and Molecular/Cell Biology.  SEE-DRUG relies on the use of a centerpiece 700MHz NMR equipment and on state-of-the-art protein expression and pharmacological evaluation technology, to identify, design and evaluate molecules that target proteins that play a key role in vascular, neural and inflammatory diseases

Successful applicants will have the opportunity to conduct research with access to state-of-the-art research facilities, and they will complement the existing UPAT’s research groups and human research capacities of the SEE-DRUG project. They are also expected to transfer knowledge and expertise to the host institution (UPAT), to train younger researchers and to perform lab management and scientific reporting. The positions offer competitive remuneration and very good prospects for professional growth.  Starting date is between January and June 2012.

 The successful candidates should be highly motivated scientists with the following qualifications:

(a) Scientific background and significant track record in fields related to the project components,
(b) Proven ability to tackle complex problems in an independent manner, and team-leadership capabilities,
(c)  Experience on the existing and anticipated equipment (High-field 700MHz NMR Spectrometer, Confocal microscope, Crystallization Robot, Intravital microscope and Myographs)
(d) Excellent oral and written communication skills, in Greek or English
(e) Ability to interact closely and productively with scientists from different disciplines (i.e. chemists, spectroscopists, biologists, bioinformaticians)

Specific expertise for the eight available positions includes: (1) polypeptide labeling strategies for NMR conformational dynamics studies, spectra analysis & peptide/protein structure determination, (2) Expertise in Bio-NMR Spectroscopy applications and significant experience in use of high-field (>600 MHz) NMR instruments and previous work in a NMR Center (a staff member of a Large NMR RIs or equivalent) to set-up new BioNMR applications at UPAT, (3) Expertise in biomolecular crystallography and modeling, for the setup of crystallization protocols and capabilities in crystal structure determination and drug design, (4) Expertise in molecular biology and biochemistry in order to perform expression, purification experiments and biophysical characterization of proteins, (5) Expertise in Confocal and Functional Microscopy for the upgrading and development of the Confocal unit and network activities, (6) Expertise in in vitro assays used in vascular biology and inflammation in order to perform cell-based assays, (7) Expertise in in vivo and ex vivo assays used in vascular biology and inflammation, and significant experience in applications of Intravital Microscopy and Myographs, (8) Expertise in data acquisition/integration, database development and curation to build an integrated platform for the collection of the data from all the collaborating groups.

Finally, a qualified technical assistant will also be hired in the framework of “SEE-DRUG” project, in order to ensure the smooth functioning of the core, 700MHz NMR equipment. The qualified person will be responsible for the maintenance and the day-to-day operation of the NMR. This person should have a good understanding of biological systems and proven ability to operate electronic devices and PC’s along with strong Unix/Linux skills. He/she will receive additional training to cover, if possible, most equipment-related applications.

The eight researchers will be recruited in the frame of the “SEE-DRUG” project (FP7-CAPACITIES, RESEARCH POTENTIAL, REGPOT-2011-1) for periods that vary from 18 to 36 months, depending on the position. Annual gross salary including social charges will be according to the qualifications.

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  • 01 Jan 2012 Starting data of SEE-DRUG project

  • 23 Feb 2012 Kick-off meeting

  • 23 Apr2012 External Advisory Board meeting

  • 29 Apr 2013 700MHz NMR installed