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“SEE-DRUG ” is a FP7 - RESEARH POTENTIAL project that aims to the upgrade the Structural Biology capacities of UPAT and to the Establishment of a Center of Excellence for Structure-Based Drug Target chracterization efforts in South-Eastern EU region.
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“SEE-STRUCT” is structure-oriented module of SEE-DRUG project and aims to the structural elucidation of proteins, enzymes and other interesting drug-targets. The tools offered for these efforts are a state-of-the-art high field NMR instrument of 700 MHz equipped with a highly sensitive probe and crystallization robot.
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“SEE-PROT” & “SEE-PHARM” are the protein production and the preclinical evaluation of molecules, modules of SEE-DRUG project. The tools offered for these efforts are protein production and characterization facilities an upgraded confocal microscope, an intravital microscope and myographs.
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High sensetivity probe
Studies in solution
3D Structure determination, mobility, protein-protein interaction, protein-drug interactions
In-cell imaging
Leica Microscope
Tandem Scanner
Additional laser
Sub-cellular ablation in live cells, protein-complexes, protein drug interactions in vivo
Crystal growth
Crystalization trials
Fast & efficient
Crystal growth optimization, screen of protein targes in paraller with NRM Spectroscopy
intravital Microscope
In vivo
Ex vivo
Drug screening for anti-inflammatory compounds, evaluation of vasoactive compounds

Stuctural Biology
NMR & Xray
2H/13C/15N labeling
Selective labeling
Conformation dynamics, Modeling Structure determination, 3D solutions & crystal models, Bioinformatics
Molecular Biology
Biochemical pathways
Protein production
High-yield protein expression, labeling & isolation for structural studies, protein biochemistry
In-cell studies
Functional imaging
Light Microscopy
FRET measurements
Studies of biomolecular functions through Advanced Light Microscopy, Sub-cellular ablations
Vascular Biology
Cell-based assays
Signaling pathways
Monitoring cell processes (migration. proliferation, apoptosis), in vivo & ex vivo assays

Expertise Exchange
Knowledge transfer
Best practices
New applications
Exchange of researchers between UPAT and partnering organizations - EU Centers of excellence
Structural Biology
Workshops and scientific meetings will be organized at UPAT, Advanced training course in NMR
Biomolecular NMR
Life Sciences
Invited talks, Meeting participation & Poster presentations by SEE-DRUG members
Brokerage Events
Meet the expers
Links with industry
Regional Authorities
Colloquia with invited speakers from academia or industry and private sector stakeholders

1st EAB Meeting, April 2012

1st EAB Meeting. The first External Advisory Board Meeting was organized at 23rd of April 2012 and participated all the SEEDRUG UPAT’s Consortium members and their teams,

Prof Ivano Bertini (Chair of the EAB) could not join the meeting due to health problems and was replaced by Prof Claudio Luchinat.

Industrial partners of the SEEDRUG project, members of the SME CBL Biopharmaceuticals Patras, (Prof K. Barlos & Prof D. Gatos) and spin-off company ELDRUG SA (Dr. Minos Matsoukas) with oral presentations and/or by taking part at the Round Table discussion.

UPAT’s authorities and Chairman of the Department of Pharmacy welcome addresses the participants.

SEEDRUG Coordinator opened the scientific part of the meeting and presented the work performed in each one of the SEEDRUG’s work packages already and the activity planned for the future (recruitment of the experienced researchers, progress on the research equipment acquisition, planned twinning & networking activities and dissemination activities).

All SEEDRUG consortium members provided an overview of their research plans through SEEDRUG project.

The members of the EAB commented on the progress made during the first 4 months of the project’s duration and on the future project’s plans. Specifically discussion included the following topics:

  • networking activities that already performed or planned.

  •  future SEEDRUG’s research orientation, with a special focus on drug design efforts and the building of a national and an international network to ensure viability of the facility for the years after the end of the SEEDRUG project.

  •  the acquisition and installation at UPAT of modern research instrumentation, which may increase the institutional networking efforts

  •  new NMR-driven initiatives, such as Magnetic Resonance Diagnostics, through NMR metabolomics.

  •  SEEDRUG consortium efforts should be made on the direction of the construction of a viability plan for the SEEDRUG capacities (instrumentation plus personnel).

Industrial SEEDRUG partners (CBL Biopharmaceutical Patras, & ELDRUG SA) participated in the meeting suggesting means and actions towards the establishment of new links between SEEDRUG and industrial partners (through service and preparation of new products).

MONDAY 23rd APRIL 2012

Conference & Cultural Center
University of Patras
Room II-9 (1st Floor)


Z. Lygerou (Dept of Medicine) & I. Margiolaki (Dept of Biology)

09:30 – 9:45Welcome Addresses - Introduction (The SEE-DRUG project)
University of Patras Authorities &
Georgios A. Spyroulias
09:45 – 10:15

Genomic Databases & personalized medicine
George Patrinos
University of Patras, Department of Pharmacy, Hellas

10:15 – 10:50

Pharmacological control of arterial smooth muscle and endothelial cell phenotype
Stavros Topouzis

University of Patras, Department of Pharmacy, Hellas

10:50 – 11:10
 EAB Member contribution

Arkadia a RING domain E3 ubiquitin ligase, supports the tumor suppressing properties of the TGFbeta pathway
Vasso Episkopou

Imperial College, London, UK

11:10 – 11:45

NMR-based Structure-Activity Correlation Study of Arkadia E3 Ubiquitin Ligase Domain
Georgios A. Spyroulias
University of Patras, Department of Pharmacy, Hellas

11:45 – 12:00Coffee Break

 G.A. Spyroulias (Dept of Pharmacy) & K. Poulas (Dept of Pharmacy)

12:00 – 12:45
EAB Member contribution

Lightening from NMR in Life Sciences
Ivano Bertini
Center of Magnetic Resonance (CERM), Florence, IT

12:45 – 13:20
SME Member contribution

Studies on the “in vitro oxidative folding” of the A and B chains of the Insulin Like Peptides (INSL)
Kleomenis Barlos
University of Patras & CBL SA Patras, Patras, Hellas

13:20 – 13:40

Factors that modulate the pKa of the attacking thiolate anion of glutaredoxin
Alexios Vlamis
University of Patras, Department of Chemistry, Hellas

13:40 – 14:00

SEE-DRUG strategic plan – Suggestions & Comments by EAB members
Ivano Bertini, Vasso Episkopou, Anastassis Perrakis & SEE-DRUG Members

14:00 – 15:30Light lunch & Coffee

 T. Tselios (Dept of Chemistry) & A. Vlamis (Dept of Chemistry)

15:30 – 16:15
EAB Member contribution

The curious story of J-base and JBP1.
Anastassis Perrakis

National Cancer Institute (NKI), Amsterdam, The Netherlands

16:15 – 16:50

Control of DNA replication in time and space
Zoi Lygerou

University of Patras, Department of Medicine, Hellas

16:50 – 17:10

Peptide-mimetics, a new generation of drugs
John Matsoukas
University of Patras, Department of Chemistry, Hellas

17:10 – 17:30Closing Remarks

Z. Lygerou  (Dept of Medicine)

Upcoming Events

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  • 01 Jan 2012 Starting data of SEE-DRUG project

  • 23 Feb 2012 Kick-off meeting

  • 23 Apr2012 External Advisory Board meeting

  • 29 Apr 2013 700MHz NMR installed