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“SEE-DRUG ” is a FP7 - RESEARH POTENTIAL project that aims to the upgrade the Structural Biology capacities of UPAT and to the Establishment of a Center of Excellence for Structure-Based Drug Target chracterization efforts in South-Eastern EU region.
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“SEE-STRUCT” is structure-oriented module of SEE-DRUG project and aims to the structural elucidation of proteins, enzymes and other interesting drug-targets. The tools offered for these efforts are a state-of-the-art high field NMR instrument of 700 MHz equipped with a highly sensitive probe and crystallization robot.
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“SEE-PROT” & “SEE-PHARM” are the protein production and the preclinical evaluation of molecules, modules of SEE-DRUG project. The tools offered for these efforts are protein production and characterization facilities an upgraded confocal microscope, an intravital microscope and myographs.
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NMR
700MHz
High sensetivity probe
Studies in solution
Conformation/Dynamics
3D Structure determination, mobility, protein-protein interaction, protein-drug interactions
Confocal
In-cell imaging
Leica Microscope
Tandem Scanner
Additional laser
Sub-cellular ablation in live cells, protein-complexes, protein drug interactions in vivo
Robot
Crystal growth
Automation
Crystalization trials
Fast & efficient
Crystal growth optimization, screen of protein targes in paraller with NRM Spectroscopy
Microscopes
Myographs
intravital Microscope
In vivo
Ex vivo
Drug screening for anti-inflammatory compounds, evaluation of vasoactive compounds

Stuctural Biology
NMR & Xray
2H/13C/15N labeling
Selective labeling
Crystallization
Conformation dynamics, Modeling Structure determination, 3D solutions & crystal models, Bioinformatics
Molecular Biology
Biochemistry
Drug-targets
Biochemical pathways
Protein production
High-yield protein expression, labeling & isolation for structural studies, protein biochemistry
Imaging
In-cell studies
Functional imaging
Light Microscopy
FRET measurements
Studies of biomolecular functions through Advanced Light Microscopy, Sub-cellular ablations
Pharmacology
Inflammation
Vascular Biology
Cell-based assays
Signaling pathways
Monitoring cell processes (migration. proliferation, apoptosis), in vivo & ex vivo assays

Expertise Exchange
Twinnings
Knowledge transfer
Best practices
New applications
Exchange of researchers between UPAT and partnering organizations - EU Centers of excellence
Events
Workshops
Structural Biology
Biochemistry
Imaging
Workshops and scientific meetings will be organized at UPAT, Advanced training course in NMR
Dissemination
Conferences
Biomolecular NMR
Life Sciences
Analysis
Invited talks, Meeting participation & Poster presentations by SEE-DRUG members
Brokerage Events
Info-days
Meet the expers
Links with industry
Regional Authorities
Colloquia with invited speakers from academia or industry and private sector stakeholders

SEE-DRUG


“SEE-DRUG ” is a FP7 - RESEARH POTENTIAL project that aims to the upgrade the Structural Biology capacities of UPAT and to the Establishment of a Center of Excellence for Structure-Based Drug Target chracterization efforts in South-Eastern EU region.


The overall strategic objective of the FP7-REGPOT-CT-2011-285950 - SEE-DRUG project is to permit the UPAT to achieve a regional centre of excellence status, using a Chemical/Structural Biology as a core component, thus contributing to the S&T and socio-economic development of the parent organization. This will be accomplished by the establishment of a multi-disciplinary platform of high-level scientific research that focuses on the development of bioactive molecules targeting important biochemical processes in cancer, cardiovascular and neurodegenerative diseases. The collaborating groups have a demonstrable track record of expertise, experience and competitiveness in each of their respective research fields and each contributes valuable, distinct and complementary competences to SEE-DRUG.

The above targets will be achieved when the existed S&T Infrastructures and expertise (Figure 1) can be integrated in a unique scientific platform in Greece and SouthEastern EU region consisting of the following modules:

  • SEE-PROT: Production of protein & peptides and screening/optimization of polypeptide samples. (Link to SEE-PROT)
  • SEE-STRUCT: Conformational dynamics, interactions & biophysical characterization. (Link to SEE-STRUCT)
  • SEE-PHARM: Disease-modelling cell-based assays including live cell imaging techniques, complemented by ex vivo and in vivo screening. (Link to SEE-PROT)

Overall, the SEE-DRUG project objectives aim to strengthen and broaden the scientific reach and socio-economic impact of the University of Patras (UPAT) through the creation of a Regional Centre of Excellence for Structural Biology that emphasizes the characterization and development of bioactive molecules with therapeutic potential.

Figure 1. Work flow diagram in the SEE-DRUG project.

The SEE-DRUG strategy is essentially based on four core activities: Exchange of technological know-how and scientific expertise, Appointment of experienced, skilled researchers, Upgrading of the UPAT S&T Infrastructure and Organization of Workshops and Conferences. This plan will incur two important long-term benefits: a) it will significantly improve the level of the research capacity of UPAT at the whole organization level, and b) it will attract high-level scientific expertise that will likely be associated with UPAT and SouthEastern EU region well after the end of the project. This combination will ensure the establishment of a centre of excellence in Structural Biology with emphasis on therapeutic molecule development, accessible to the entire SEE region research community. It is also bound to create new links among EU Centres of Excellence, scientists, industrial and regional stakeholders in Achaia and the Western Greece region, overall contributing to the socio-economic development and public awareness for research in health-related research. In particular, the SEE-DRUG project Action Plan

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  • 01 Jan 2012 Starting data of SEE-DRUG project

  • 23 Feb 2012 Kick-off meeting

  • 23 Apr2012 External Advisory Board meeting

  • 29 Apr 2013 700MHz NMR installed